Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
birAbiotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (327 aa)    
Predicted Functional Partners:
Toce_2272
Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR006638:IPR005244:IPR007197; KEGG: amt:Amet_4104 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; PFAM: Radical SAM superfamily; Protein of unknown function (DUF3343).
  
 
 0.971
Toce_1893
Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family.
 
    0.939
Toce_1829
Biotin/lipoyl attachment domain-containing protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR000089:IPR001882; KEGG: afn:Acfer_1835 biotin/lipoyl attachment domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Methylmalonyl-CoA decarboxylase, gamma-subunit; PFAM: Biotin-requiring enzyme.
 
  
 0.934
Toce_1194
Biotin/lipoyl attachment domain-containing protein; COGs: COG0511 Biotin carboxyl carrier protein; InterPro IPR000089:IPR001882; KEGG: tai:Taci_0293 biotin/lipoyl attachment domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Biotin/lipoyl attachment domain-containing protein; PFAM: Biotin-requiring enzyme.
 
  
 0.933
tadA
tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
    0.916
Toce_1196
COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR000022:IPR011762:IPR011763; KEGG: amt:Amet_4538 carboxyl transferase; PFAM: carboxyl transferase; SPTR: Carboxyl transferase; PFAM: Carboxyl transferase domain; TIGRFAM: methylmalonyl-CoA decarboxylase alpha subunit.
 
 
 0.914
Toce_1831
COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR000022:IPR011762:IPR011763; KEGG: amt:Amet_4538 carboxyl transferase; PFAM: carboxyl transferase; SPTR: Carboxyl transferase; PFAM: Carboxyl transferase domain; TIGRFAM: methylmalonyl-CoA decarboxylase alpha subunit.
 
 
 0.914
Toce_1495
Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR002646:IPR006674; KEGG: bhy:BHWA1_01411 polyA polymerase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; SPTR: Uncharacterized domain HDIG-containing protein; PFAM: HD domain; Poly A polymerase head domain.
 
  
 0.878
coaX
Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
 
    0.865
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.
  
  
 0.852
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (14%) [HD]