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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_0930COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR003607:IPR006261:IPR006674; KEGG: tpd:Teth39_0737 deoxyguanosinetriphosphate triphosphohydrolase-like protein; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily. (335 aa)    
Predicted Functional Partners:
Toce_0512
COGs: COG0232 dGTP triphosphohydrolase; InterPro IPR006261:IPR003607:IPR006674; KEGG: tkm:TK90_0267 deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Deoxyguanosinetriphosphate triphosphohydrolase; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: HD domain; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase, putative; Belongs to the dGTPase family. Type 2 subfamily.
  
  
 
0.915
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.906
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
  0.902
Toce_0595
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.900
Toce_0871
COGs: COG0469 Pyruvate kinase; InterProIPR001697:IPR018209:IPR015793:IPR015794:IPR 008279; KEGG: tte:TTE1815 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
     
  0.900
Toce_1667
2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterProIPR004843:IPR008334:IPR001119:IPR006179:IPR 006146; KEGG: cpo:COPRO5265_0800 multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; S-layer domain protein; PRIAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; SPTR: Multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-nucleotidase, C-termin [...]
     
  0.900
Toce_1992
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR012833:IPR005144; KEGG: ate:Athe_0548 anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
     
  0.900
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
    
 0.845
sigA
RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
     
 0.594
Toce_0935
Protein of unknown function DUF34; COGs: COG3323 conserved hypothetical protein; InterPro IPR002678:IPR017221; KEGG: tit:Thit_1543 protein of unknown function DUF34; PFAM: protein of unknown function DUF34; SPTR: Putative uncharacterized protein; manually curated; PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: conserved hypothetical protein TIGR00486; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
       0.570
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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