close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (461 aa)    
Predicted Functional Partners:
mraY
Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
 
 0.999
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
 
0.997
ddl
D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.
 
 0.995
murG
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.992
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
  
0.987
Toce_0042
Cyanophycin synthetase; COGs: COG0769 UDP-N-acetylmuramyl tripeptide synthase; InterProIPR011810:IPR005479:IPR013221:IPR004101:IPR 018109:IPR011761; KEGG: tte:TTE2785 cyanophycin synthetase; PFAM: Mur ligase middle domain protein; Carbamoyl-phosphate synthase L chain ATP-binding; cytoplasmic peptidoglycan synthetase domain protein; SPTR: UDP-N-acetylmuramyl tripeptide synthase; TIGRFAM: cyanophycin synthetase; PFAM: RimK-like ATP-grasp domain; Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Str [...]
  
  
0.978
Toce_0466
COGs: COG1181 D-alanine-D-alanine ligase and related ATP-grasp protein; InterPro IPR011761:IPR011095; KEGG: tpd:Teth39_2176 D-alanine--D-alanine ligase; PFAM: D-alanine--D-alanine ligase domain protein; PRIAM: D-alanine--D-alanine ligase; SPTR: D-alanine--D-alanine ligase; PFAM: D-ala D-ala ligase C-terminus; TIGRFAM: D-alanine--D-alanine ligase.
 
 
 0.968
Toce_0946
COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR005543:IPR005311:IPR001460:IPR011927; KEGG: hor:Hore_09030 stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein; PRIAM: Peptidoglycan glycosyltransferase; SMART: PASTA domain containing protein; SPTR: Stage V sporulation protein D; TIGRFAM: stage V sporulation protein D; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; PASTA domain; TIGRFAM: sta [...]
 
  
 0.961
Toce_0951
Spore cortex peptidoglycan biosynthesis regulator SpoVE; COGs: COG0772 Bacterial cell division membrane protein; InterPro IPR001182:IPR013437:IPR013438; KEGG: afl:Aflv_1831 stage V sporulation protein E required for spore cortex peptidoglycan synthesis; PFAM: cell cycle protein; SPTR: Stage V sporulation protein E required for spore cortex peptidoglycan synthesis; TIGRFAM: stage V sporulation protein E; cell division protein FtsW; PFAM: Cell cycle protein; TIGRFAM: stage V sporulation protein E; cell division protein FtsW; Belongs to the SEDS family.
 
 
 0.960
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
  
0.952
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.