STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prsAPpiC-type peptidyl-prolyl cis-trans isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (297 aa)    
Predicted Functional Partners:
Toce_2197
Peptidoglycan-binding domain 1 protein; COGs: COG1520 FOG: WD40-like repeat; InterPro IPR018391:IPR002477:IPR002372; KEGG: chl:Chy400_4120 serine/threonine protein kinase; PFAM: Peptidoglycan-binding domain 1 protein; Pyrrolo-quinoline quinone; SPTR: Similar to beta-propeller protein YxaL; PFAM: Putative peptidoglycan binding domain; PQQ enzyme repeat.
   
 
 0.801
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.595
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.525
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
  
 0.516
Toce_1075
KEGG: smm:Smp_043860 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.507
Toce_1077
MATE efflux family protein; COGs: COG0534 Na+-driven multidrug efflux pump; InterPro IPR002528; KEGG: bhy:BHWA1_00467 NorM, Na+-driven multidrug efflux pump; PFAM: multi antimicrobial extrusion protein MatE; SPTR: Putative uncharacterized protein; TIGRFAM: MATE efflux family protein; PFAM: MatE; TIGRFAM: putative efflux protein, MATE family.
   
   0.505
Toce_2282
Membrane protein insertase, YidC/Oxa1 family; COGs: COG0706 Preprotein translocase subunit YidC; InterPro IPR001708:IPR020001; KEGG: tpd:Teth39_2292 60 kDa inner membrane insertion protein; PFAM: 60 kDa inner membrane insertion protein; SPTR: 60 kDa inner membrane insertion protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family; PFAM: 60Kd inner membrane protein; TIGRFAM: membrane protein insertase, YidC/Oxa1 family, C-terminal domain.
 
  
 0.505
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
  
 0.504
Toce_1029
Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.488
Toce_1225
COGs: COG0740 Protease subunit of ATP-dependent Clp protease; InterPro IPR001907; KEGG: mta:Moth_1071 ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S14 ClpP; SPTR: ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: Clp protease.
  
 
 0.456
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.