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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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xerDTyrosine recombinase XerD subunit; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (299 aa)    
Predicted Functional Partners:
Toce_1272
Stage II sporulation protein M; InterPro IPR014196:IPR002798; KEGG: aoe:Clos_1594 sporulation stage II protein M; PFAM: protein of unknown function DUF95 transmembrane; SPTR: Sporulation stage II protein M; TIGRFAM: stage II sporulation protein M; PFAM: Integral membrane protein DUF95; TIGRFAM: stage II sporulation protein M.
  
    0.673
Toce_1270
Serine-type D-Ala-D-Ala carboxypeptidase; COGs: COG1686 D-alanyl-D-alanine carboxypeptidase; InterPro IPR001967:IPR012907:IPR018044; KEGG: aoe:Clos_1588 serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; PRIAM: Serine-type D-Ala-D-Ala carboxypeptidase; SPTR: Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: D-alanyl-D-alanine carboxypeptidase; Penicillin-binding protein 5, C-terminal domain; Belongs to the peptidase S11 family.
       0.618
Toce_1274
NUDIX hydrolase; InterPro IPR000086:IPR020084; KEGG: tte:TTE1310 NTP pyrophosphohydrolase including oxidative damage repair enzyme; PFAM: NUDIX hydrolase; SPTR: NTP pyrophosphohydrolases including oxidative damage repair enzymes; PFAM: NUDIX domain; TIGRFAM: nudix hydrolase, YffH family.
  
    0.536
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.518
Toce_1601
COGs: COG1040 amidophosphoribosyltransferase; KEGG: dal:Dalk_1937 phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
   
    0.515
Toce_1223
DNA translocase FtsK; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR003593:IPR002543:IPR018541; KEGG: pth:PTH_1293 DNA segregation ATPase FtsK/SpoIIIE and related proteins; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SMART: AAA ATPase; SPTR: DNA segregation ATPase FtsK/SpoIIIE and related proteins; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family.
 
   
 0.503
Toce_1275
KEGG: drm:Dred_1093 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.492
Toce_1273
PHP domain protein; COGs: COG1379 conserved hypothetical protein; InterPro IPR004013; KEGG: tte:TTE1311 hypothetical protein; PFAM: PHP domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: conserved hypothetical protein TIGR00375.
       0.490
Toce_1277
KEGG: tte:TTE1306 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3186).
  
    0.489
Toce_1278
Thiamin pyrophosphokinase catalytic region; COGs: COG4825 Uncharacterized membrane-anchored protein; InterPro IPR007371:IPR000209; KEGG: tit:Thit_1099 thiamin pyrophosphokinase catalytic region; PFAM: Thiamin pyrophosphokinase catalytic region; SPTR: Thiamin pyrophosphokinase catalytic region; PFAM: Thiamine pyrophosphokinase C terminal; Thiamin pyrophosphokinase, catalytic domain.
  
    0.479
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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