Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (237 aa)    
Predicted Functional Partners:
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.961
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.948
Toce_0103
MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR011551:IPR004518; KEGG: tpd:Teth39_0248 MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: MazG family protein; TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein.
     
  0.900
Toce_1386
Protein of unknown function UPF0029; COGs: COG1739 conserved hypothetical protein; InterPro IPR015796:IPR001498:IPR015269; KEGG: cth:Cthe_2078 hypothetical protein; PFAM: protein of unknown function UPF0029; Domain of unknown function DUF1949; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein family UPF0029; Domain of unknown function (DUF1949); TIGRFAM: conserved hypothetical protein TIGR00257.
       0.757
cutC
CutC family protein; Participates in the control of copper homeostasis. Belongs to the CutC family.
    
   0.752
Toce_1650
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638:IPR007229; KEGG: tte:TTE0877 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; SPTR: Quinolinate phosphoribosyl transferase, C-terminal domain protein; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; Belongs to the NAPRTase family.
 
  
 0.740
Toce_1695
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.690
cinA
Competence/damage-inducible protein cinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR001453:IPR008136:IPR008135; KEGG: dtu:Dtur_0064 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: CinA-like protein; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor [...]
     
 0.689
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.686
Toce_1384
Protein of unknown function DUF28; COGs: COG0217 conserved hypothetical protein; InterPro IPR002876; KEGG: tpd:Teth39_1009 hypothetical protein; PFAM: protein of unknown function DUF28; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function DUF28; TIGRFAM: conserved hypothetical protein TIGR01033.
   
   0.666
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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