| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_0317 | Toce_0318 | Toce_0317 | Toce_0318 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | 0.999 |
| Toce_0317 | Toce_1083 | Toce_0317 | Toce_1083 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | 0.416 |
| Toce_0317 | Toce_1419 | Toce_0317 | Toce_1419 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR017578:IPR013078:IPR001345; KEGG: adg:Adeg_1465 alpha-ribazole phosphatase; PFAM: Phosphoglycerate mutase; SPTR: Alpha-ribazole phosphatase; TIGRFAM: alpha-ribazole phosphatase; PFAM: Phosphoglycerate mutase family; TIGRFAM: alpha-ribazole phosphatase. | 0.402 |
| Toce_0317 | Toce_1422 | Toce_0317 | Toce_1422 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. | 0.404 |
| Toce_0317 | Toce_1424 | Toce_0317 | Toce_1424 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: aoe:Clos_2210 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. | 0.475 |
| Toce_0317 | cbiA | Toce_0317 | Toce_0308 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.971 |
| Toce_0317 | cobD | Toce_0317 | Toce_1421 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.757 |
| Toce_0317 | cobQ | Toce_0317 | Toce_0449 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.991 |
| Toce_0317 | cobS | Toce_0317 | Toce_1420 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.945 |
| Toce_0317 | cobT | Toce_0317 | Toce_0158 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Nicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.477 |
| Toce_0318 | Toce_0317 | Toce_0318 | Toce_0317 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.999 |
| Toce_0318 | Toce_1083 | Toce_0318 | Toce_1083 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | 0.445 |
| Toce_0318 | Toce_1419 | Toce_0318 | Toce_1419 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR017578:IPR013078:IPR001345; KEGG: adg:Adeg_1465 alpha-ribazole phosphatase; PFAM: Phosphoglycerate mutase; SPTR: Alpha-ribazole phosphatase; TIGRFAM: alpha-ribazole phosphatase; PFAM: Phosphoglycerate mutase family; TIGRFAM: alpha-ribazole phosphatase. | 0.447 |
| Toce_0318 | Toce_1424 | Toce_0318 | Toce_1424 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: aoe:Clos_2210 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. | 0.490 |
| Toce_0318 | cbiA | Toce_0318 | Toce_0308 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.988 |
| Toce_0318 | cobD | Toce_0318 | Toce_1421 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.748 |
| Toce_0318 | cobQ | Toce_0318 | Toce_0449 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.965 |
| Toce_0318 | cobS | Toce_0318 | Toce_1420 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.814 |
| Toce_0318 | cobT | Toce_0318 | Toce_0158 | COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | Nicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.520 |
| Toce_1083 | Toce_0317 | Toce_1083 | Toce_0317 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR006363:IPR000878; KEGG: tit:Thit_0358 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-3B C17-methyltransferase; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.416 |