Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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Toce_1423GHMP kinase; COGs: COG4542 Protein involved in propanediol utilization and related protein (includes coumermycin biosynthetic protein) possible kinase; InterPro IPR006204:IPR013750:IPR012363; KEGG: mta:Moth_1103 GHMP kinase; PFAM: GHMP kinase; GHMP kinase domain protein; SPTR: GHMP kinase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain. (300 aa)    
Predicted Functional Partners:
Toce_1422
L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase.
  
 
 0.987
Toce_0316
COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: tit:Thit_0357 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal.
  
  
 0.936
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
     
 0.828
Toce_1424
Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: aoe:Clos_2210 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase.
  
    0.773
cbiD
Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
  
  
 0.723
Toce_0306
Cobalt ABC transporter, inner membrane subunit CbiQ; COGs: COG0619 ABC-type cobalt transport system permease component CbiQ and related transporter; InterPro IPR012809:IPR003339; KEGG: tit:Thit_0370 cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein; SPTR: Cobalt ABC transporter, inner membrane subunit CbiQ; TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: Cobalt transport protein; TIGRFAM: cobalt ABC transporter, permease protein CbiQ.
  
    0.705
Toce_0318
COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: tit:Thit_0359 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase.
 
  
 0.676
Toce_0559
ATP/cobalamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR017858:IPR009221:IPR002779:IPR005624; KEGG: tex:Teth514_1943 ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; protein of unknown function DUF336; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP--cobalamin adenosyltransferase; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: Domain of unknown function (DUF336); Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase.
     
 0.670
Toce_1426
Periplasmic binding protein; COGs: COG0614 ABC-type Fe3+-hydroxamate transport system periplasmic component; InterPro IPR002491; KEGG: dau:Daud_1317 periplasmic binding protein; PFAM: periplasmic binding protein; SPTR: Periplasmic binding protein; PFAM: Periplasmic binding protein.
     
 0.669
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
    0.666
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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