| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_0315 | Toce_1083 | Toce_0315 | Toce_1083 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | 0.445 |
| Toce_0315 | Toce_1422 | Toce_0315 | Toce_1422 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. | 0.633 |
| Toce_0315 | Toce_1423 | Toce_0315 | Toce_1423 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | GHMP kinase; COGs: COG4542 Protein involved in propanediol utilization and related protein (includes coumermycin biosynthetic protein) possible kinase; InterPro IPR006204:IPR013750:IPR012363; KEGG: mta:Moth_1103 GHMP kinase; PFAM: GHMP kinase; GHMP kinase domain protein; SPTR: GHMP kinase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain. | 0.613 |
| Toce_0315 | Toce_1424 | Toce_0315 | Toce_1424 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: aoe:Clos_2210 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. | 0.837 |
| Toce_0315 | cbiA | Toce_0315 | Toce_0308 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.979 |
| Toce_0315 | cobD | Toce_0315 | Toce_1421 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.690 |
| Toce_0315 | cobQ | Toce_0315 | Toce_0449 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.947 |
| Toce_0315 | cobS | Toce_0315 | Toce_1420 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.622 |
| Toce_0315 | cobT | Toce_0315 | Toce_0158 | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Nicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.494 |
| Toce_1083 | Toce_0315 | Toce_1083 | Toce_0315 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.445 |
| Toce_1083 | Toce_1424 | Toce_1083 | Toce_1424 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: aoe:Clos_2210 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. | 0.963 |
| Toce_1083 | cbiA | Toce_1083 | Toce_0308 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.963 |
| Toce_1083 | cobD | Toce_1083 | Toce_1421 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.958 |
| Toce_1083 | cobQ | Toce_1083 | Toce_0449 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.990 |
| Toce_1083 | cobS | Toce_1083 | Toce_1420 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.961 |
| Toce_1083 | cobT | Toce_1083 | Toce_0158 | cob(I)yrinic acid a,c-diamide adenosyltransferase; COGs: COG2109 ATP:corrinoid adenosyltransferase; InterPro IPR003724; KEGG: tte:TTE0526 ATP:corrinoid adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP:corrinoid adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. | Nicotinate-nucleotide/dimethylbenzimidazolephosp horibosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.556 |
| Toce_1422 | Toce_0315 | Toce_1422 | Toce_0315 | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR006362:IPR000878:IPR003043; KEGG: tex:Teth514_0313 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.633 |
| Toce_1422 | Toce_1423 | Toce_1422 | Toce_1423 | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. | GHMP kinase; COGs: COG4542 Protein involved in propanediol utilization and related protein (includes coumermycin biosynthetic protein) possible kinase; InterPro IPR006204:IPR013750:IPR012363; KEGG: mta:Moth_1103 GHMP kinase; PFAM: GHMP kinase; GHMP kinase domain protein; SPTR: GHMP kinase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain. | 0.987 |
| Toce_1422 | Toce_1424 | Toce_1422 | Toce_1424 | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. | Adenosylcobinamide-phosphateguanylyltransferase; COGs: COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase; InterPro IPR003203; KEGG: aoe:Clos_2210 adenosylcobinamide-phosphate guanylyltransferase; PFAM: cobalbumin biosynthesis protein; PRIAM: Adenosylcobinamide-phosphate guanylyltransferase; SPTR: Adenosylcobinamide kinase; PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. | 0.896 |
| Toce_1422 | Toce_1425 | Toce_1422 | Toce_1425 | L-threonine-O-3-phosphate decarboxylase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005860:IPR004839:IPR004838; KEGG: cpe:CPE1040 threonine-phosphate decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative L-threonine-O-3-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase. | COGs: COG0609 ABC-type Fe3+-siderophore transport system permease component; InterPro IPR000522; KEGG: aoe:Clos_0916 transport system permease protein; PFAM: transport system permease protein; SPTR: Transport system permease protein; PFAM: FecCD transport family; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. | 0.681 |