Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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Toce_1433SAF domain protein; COGs: COG4091 homoserine dehydrogenase; InterPro IPR005106:IPR013974; KEGG: str:Sterm_3777 SAF domain protein; PFAM: SAF domain protein; homoserine dehydrogenase NAD-binding; SPTR: SAF domain protein; PFAM: Homoserine dehydrogenase, NAD binding domain; SAF domain. (430 aa)    
Predicted Functional Partners:
Toce_1434
COGs: COG3731 Phosphotransferase system sorbitol-specific component IIA; InterPro IPR004716; KEGG: chl:Chy400_1450 PTS system glucitol/sorbitol-specific IIA component; PFAM: PTS system glucitol/sorbitol-specific IIA component; SPTR: PTS system glucitol/sorbitol-specific IIA component; PFAM: PTS system glucitol/sorbitol-specific IIA component.
 
     0.898
Toce_1436
PTS system, glucitol/sorbitol-specific, IIC subunit; COGs: COG3730 Phosphotransferase system sorbitol-specific component IIC; InterPro IPR004699; KEGG: bha:BH0771 PTS system, glucitol/sorbitol-specific enzyme II, C2 component (permease); PFAM: PTS system protein II sorbitol-specific factor; SPTR: PTS system, glucitol/sorbitol-specific enzyme II, C2 component (Permease); TIGRFAM: PTS system, glucitol/sorbitol-specific, IIC subunit; PFAM: PTS system enzyme II sorbitol-specific factor; TIGRFAM: PTS system, glucitol/sorbitol-specific, IIC component.
 
     0.867
Toce_1435
COGs: COG3732 Phosphotransferase system sorbitol-specific component IIBC; InterPro IPR011618:IPR011638; KEGG: bha:BH0772 PTS system, glucitol/sorbitol-specific enzyme II, BC component (EIIBC-GUT); PFAM: Sorbitol phosphotransferase protein II domain protein; PRIAM: Protein-N(pi)-phosphohistidine--sugar phosphotransferase; SPTR: PTS system, glucitol/sorbitol-specific enzyme II, BC component (EIIBC-GUT); PFAM: Sorbitol phosphotransferase enzyme II C-terminus; Sorbitol phosphotransferase enzyme II N-terminus; TIGRFAM: PTS system, glucitol/sorbitol-specific, IIBC component.
 
     0.866
Toce_1437
COGs: COG4578 Glucitol operon activator; InterPro IPR009693; KEGG: cby:CLM_3883 glucitol operon activator protein; PFAM: Glucitol operon activator; SPTR: Glucitol operon activator protein; PFAM: Glucitol operon activator protein (GutM).
 
     0.803
Toce_1438
Transcriptional regulator, DeoR family; COGs: COG2390 Transcriptional regulator contains sigma factor-related N-terminal domain; InterPro IPR013249:IPR007324:IPR012318; KEGG: str:Sterm_3767 transcriptional regulator, DeoR family; PFAM: putative sugar-binding domain protein; Sigma-70 region 4 type 2; SPTR: Transcriptional regulator, DeoR family; PFAM: Sigma-70, region 4; Putative sugar-binding domain.
 
     0.655
Toce_1444
PTS system D-arabitol-specific IIC component, Gat family (TC 4.A.5.1.2); COGs: COG3775 Phosphotransferase system galactitol-specific IIC component; InterPro IPR013853:IPR004703:IPR013014; KEGG: cbe:Cbei_2500 PTS system galactitol-specific IIC component; PFAM: PTS system Galactitol-specific IIC component; SPTR: PTS system, galactitol-specific IIC subunit; TIGRFAM: PTS system, galactitol-specific IIC subunit; PFAM: PTS system sugar-specific permease component; TIGRFAM: PTS system, galactitol-specific IIC component.
 
     0.609
pdhA
Dehydrogenase E1 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
       0.493
Toce_1431
Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: tte:TTE0187 thiamine pyrophosphate-dependent dehydrogenase, E1 component beta subunit; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
       0.450
Toce_1430
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: tte:TTE0188 dihydrolipoamide acyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: 2-oxo acid dehydrogenases acyltransferase (Catalytic domain) protein; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...]
       0.417
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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