Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Toce_1469Domain of unknown function DUF1730; COGs: COG1600 Uncharacterized Fe-S protein; InterPro IPR013542:IPR017896:IPR017900; KEGG: gyc:GYMC61_1368 iron-sulfur cluster binding protein; PFAM: domain of unknown function DUF1730; SPTR: Hypothetical conserved protein; PFAM: 4Fe-4S binding domain; Domain of unknown function (DUF1730); TIGRFAM: iron-sulfur cluster binding protein, putative. (339 aa)    
Predicted Functional Partners:
Toce_0221
methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
      0.907
queA
S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
  
 0.756
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
     
 0.673
Toce_1769
Beta-phosphoglucomutase; COGs: COG0637 phosphatase/phosphohexomutase; InterProIPR010972:IPR010976:IPR006402:IPR005834:IPR 005833; KEGG: tte:TTE0802 phosphatase/phosphohexomutase; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Predicted phosphatase/phosphohexomutase; TIGRFAM: beta-phosphoglucomutase; beta-phosphoglucomutase family hydrolase; HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: beta-phosphoglucomutase; haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; beta-phosphog [...]
      0.591
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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