Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Toce_1545Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR001789:IPR000792; KEGG: cac:CAC0174 response regulator; PFAM: regulatory protein LuxR; response regulator receiver; SMART: regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family. (327 aa)    
Predicted Functional Partners:
Toce_0369
COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
 
 0.933
Toce_0372
Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
  
 
 0.704
Toce_1029
Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.620
Toce_1588
COGs: COG0438 Glycosyltransferase; InterProIPR001296:IPR013216:IPR001173:IPR019734:IPR 013026:IPR000276; KEGG: tnp:Tnap_0554 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; Methyltransferase type 11; glycosyl transferase group 1; SMART: Tetratricopeptide repeat; SPTR: Glycosyl transferase family 2; PFAM: Methyltransferase domain; Glycosyl transferases group 1; Glycosyl transferase family 2.
  
  
 0.527
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.484
Toce_2250
Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR018335:IPR000595:IPR012318:IPR001808; KEGG: aoe:Clos_2132 Crp/FNR family transcriptional regulator; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
  
 
 0.469
Toce_0200
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR004358:IPR005467; KEGG: bld:BLi00981 hypothetical protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
  
 
 0.407
Toce_0459
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR005467:IPR003594:IPR004358; KEGG: cbe:Cbei_4175 signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
 0.407
Toce_0694
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003594:IPR005467:IPR004358; KEGG: cpy:Cphy_3802 histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
 0.407
Toce_0460
Response regulator receiver protein; COGs: COG0784 FOG: CheY-like receiver; InterPro IPR001789:IPR013972; KEGG: cbe:Cbei_4174 response regulator receiver; PFAM: YcbB domain protein; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver; PFAM: Response regulator receiver domain; YcbB domain.
  
 
 0.406
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.