Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Toce_1550Transcriptional regulator, LysR family; COGs: COG0583 Transcriptional regulator; InterPro IPR000847:IPR005119; KEGG: tex:Teth514_0147 LysR family transcriptional regulator; PFAM: regulatory protein LysR; LysR substrate-binding; SPTR: Transcriptional regulator, LysR family; PFAM: LysR substrate binding domain; Bacterial regulatory helix-turn-helix protein, lysR family. (298 aa)    
Predicted Functional Partners:
Toce_2250
Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR018335:IPR000595:IPR012318:IPR001808; KEGG: aoe:Clos_2132 Crp/FNR family transcriptional regulator; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
  
 
 0.777
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.768
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.736
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
 
 0.730
sigA
RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.728
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.715
Toce_1549
NADH:flavin oxidoreductase/NADH oxidase; COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR001155:IPR013027:IPR000103; KEGG: tex:Teth514_0146 NADH:flavin oxidoreductase/NADH oxidase; PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: NADH:flavin oxidoreductase/NADH oxidase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NADH:flavin oxidoreductase / NADH oxidase family.
 
  
 0.639
Toce_1548
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670; KEGG: tex:Teth514_0145 iron-containing alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; SPTR: Iron-containing alcohol dehydrogenase; PFAM: Iron-containing alcohol dehydrogenase.
 
  
 0.608
Toce_0243
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR001041:IPR013027:IPR006963:IPR006656:IPR 000759:IPR017900:IPR006655:IPR017896; KEGG: aoe:Clos_0277 molybdopterin oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; ferredoxin; molybdopterin oxidoreductase Fe4S4 region; molybdopterin oxidoreductase; SPTR: Molybdopterin oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Molybdopterin oxidoreductase; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: glutamate synt [...]
   
 
 0.501
Toce_1588
COGs: COG0438 Glycosyltransferase; InterProIPR001296:IPR013216:IPR001173:IPR019734:IPR 013026:IPR000276; KEGG: tnp:Tnap_0554 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; Methyltransferase type 11; glycosyl transferase group 1; SMART: Tetratricopeptide repeat; SPTR: Glycosyl transferase family 2; PFAM: Methyltransferase domain; Glycosyl transferases group 1; Glycosyl transferase family 2.
   
  
 0.476
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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