Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Toce_1640COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; InterPro IPR012904:IPR003265; KEGG: tte:TTE0574 3-methyladenine DNA glycosylase; PFAM: 8-oxoguanine DNA glycosylase domain protein; HhH-GPD family protein; SMART: HhH-GPD family protein; SPTR: 3-Methyladenine DNA glycosylase; PFAM: 8-oxoguanine DNA glycosylase, N-terminal domain; HhH-GPD superfamily base excision DNA repair protein; TIGRFAM: 8-oxoguanine DNA-glycosylase (ogg). (292 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.584
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
   
 
 0.578
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 
 0.576
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
    0.570
Toce_1641
COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: tte:TTE1807 nitroreductase; PFAM: nitroreductase; SPTR: Nitroreductase; PFAM: Nitroreductase family.
       0.460
Toce_1005
Hypothetical protein; KEGG: tte:TTE1601 membrane-fusion protein; SPTR: Membrane-fusion protein; TIGRFAM: putative membrane fusion protein.
  
    0.452
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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