STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_1656Purine or other phosphorylase family 1; COGs: COG0775 Nucleoside phosphorylase; InterPro IPR000845; KEGG: dth:DICTH_0360 hypothetical protein; PFAM: purine or other phosphorylase family 1; SPTR: Putative uncharacterized protein; PFAM: Phosphorylase superfamily. (278 aa)    
Predicted Functional Partners:
Toce_1655
Radical SAM domain protein; COGs: COG1533 DNA repair photolyase; InterPro IPR007197; KEGG: csc:Csac_0382 DNA repair photolyase-like protein; PFAM: Radical SAM domain protein; SPTR: DNA repair photolyase-like protein; manually curated.
   
 0.984
luxS
Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
  
 
 0.929
Toce_0364
Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage.
    
 0.908
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
    
 0.901
Toce_1011
Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
     
  0.900
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.566
Toce_1383
KEGG: tte:TTE1137 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Domain of unkown function (DUF1901).
  
     0.547
Toce_2007
KEGG: swo:Swol_2165 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.537
Toce_2017
Protein of unknown function DUF1779; InterPro IPR014794; KEGG: tpd:Teth39_2101 hypothetical protein; PFAM: Protein of unknown function DUF1779; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1779).
  
     0.533
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
  
 0.526
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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