Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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Toce_16672',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterProIPR004843:IPR008334:IPR001119:IPR006179:IPR 006146; KEGG: cpo:COPRO5265_0800 multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; S-layer domain protein; PRIAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; SPTR: Multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-nucleotidase, C-termin [...] (1215 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.966
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.925
Toce_0593
COGs: COG0213 Thymidine phosphorylase; InterProIPR017872:IPR018090:IPR000053:IPR017459:IPR 000312:IPR013102; KEGG: csc:Csac_2318 pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Glycosyl transferase, family 3-like; Pyrimidine nucleoside phosphorylase domain; SPTR: Thymidine phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: Glycosyl transferase family, a/b domain; Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: pyrimidine-nucleoside phosphorylase.
 
  
 0.921
Toce_1604
COGs: COG0572 Uridine kinase; KEGG: amt:Amet_3643 phosphoribulokinase/uridine kinase; SPTR: Phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase / Uridine kinase family.
  
 
 0.920
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.918
Toce_1174
COGs: COG0015 Adenylosuccinate lyase; InterPro IPR000362:IPR019468:IPR020557:IPR004769; KEGG: tte:TTE1367 adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; SPTR: Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.918
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.917
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.917
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.916
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
 0.914
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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