| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_1625 | Toce_1626 | Toce_1625 | Toce_1626 | COGs: COG0450 Peroxiredoxin; InterPro IPR000866; KEGG: drt:Dret_1862 peroxiredoxin-like protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Peroxiredoxin-like protein; PFAM: AhpC/TSA family. | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COGs: COG0450 Peroxiredoxin; InterPro IPR000866:IPR017936; KEGG: dal:Dalk_1204 alkyl hydroperoxide reductase; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Alkyl hydroperoxide reductase; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family. | 0.863 |
| Toce_1625 | Toce_1781 | Toce_1625 | Toce_1781 | COGs: COG0450 Peroxiredoxin; InterPro IPR000866; KEGG: drt:Dret_1862 peroxiredoxin-like protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Peroxiredoxin-like protein; PFAM: AhpC/TSA family. | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | 0.406 |
| Toce_1626 | Toce_1625 | Toce_1626 | Toce_1625 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COGs: COG0450 Peroxiredoxin; InterPro IPR000866:IPR017936; KEGG: dal:Dalk_1204 alkyl hydroperoxide reductase; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Alkyl hydroperoxide reductase; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family. | COGs: COG0450 Peroxiredoxin; InterPro IPR000866; KEGG: drt:Dret_1862 peroxiredoxin-like protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Peroxiredoxin-like protein; PFAM: AhpC/TSA family. | 0.863 |
| Toce_1626 | Toce_1781 | Toce_1626 | Toce_1781 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COGs: COG0450 Peroxiredoxin; InterPro IPR000866:IPR017936; KEGG: dal:Dalk_1204 alkyl hydroperoxide reductase; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Alkyl hydroperoxide reductase; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family. | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | 0.444 |
| Toce_1667 | Toce_1781 | Toce_1667 | Toce_1781 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterProIPR004843:IPR008334:IPR001119:IPR006179:IPR 006146; KEGG: cpo:COPRO5265_0800 multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; S-layer domain protein; PRIAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; SPTR: Multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-nucleotidase, C-termin [...] | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | 0.468 |
| Toce_1667 | Toce_1782 | Toce_1667 | Toce_1782 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterProIPR004843:IPR008334:IPR001119:IPR006179:IPR 006146; KEGG: cpo:COPRO5265_0800 multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; S-layer domain protein; PRIAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; SPTR: Multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-nucleotidase, C-termin [...] | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.903 |
| Toce_1780 | Toce_1781 | Toce_1780 | Toce_1781 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | 0.698 |
| Toce_1780 | Toce_1782 | Toce_1780 | Toce_1782 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.667 |
| Toce_1780 | Toce_1784 | Toce_1780 | Toce_1784 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | Lipoprotein LpqB, GerMN domain protein; COGs: COG5401 Spore germination protein; InterPro IPR019606; KEGG: aoe:Clos_0556 hypothetical protein; PFAM: Lipoprotein LpqB, GerMN domain; SPTR: Putative uncharacterized protein; PFAM: Sporulation and spore germination. | 0.598 |
| Toce_1780 | Toce_1785 | Toce_1780 | Toce_1785 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | Protein of unknown function DUF2179; COGs: COG4843 conserved hypothetical protein; InterPro IPR019264; KEGG: aoe:Clos_0555 hypothetical protein; PFAM: Protein of unknown function DUF2179; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2179). | 0.452 |
| Toce_1780 | birA | Toce_1780 | Toce_0887 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.507 |
| Toce_1780 | rph | Toce_1780 | Toce_1783 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.666 |
| Toce_1781 | Toce_1625 | Toce_1781 | Toce_1625 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | COGs: COG0450 Peroxiredoxin; InterPro IPR000866; KEGG: drt:Dret_1862 peroxiredoxin-like protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Peroxiredoxin-like protein; PFAM: AhpC/TSA family. | 0.406 |
| Toce_1781 | Toce_1626 | Toce_1781 | Toce_1626 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COGs: COG0450 Peroxiredoxin; InterPro IPR000866:IPR017936; KEGG: dal:Dalk_1204 alkyl hydroperoxide reductase; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; SPTR: Alkyl hydroperoxide reductase; PFAM: C-terminal domain of 1-Cys peroxiredoxin; AhpC/TSA family. | 0.444 |
| Toce_1781 | Toce_1667 | Toce_1781 | Toce_1667 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterProIPR004843:IPR008334:IPR001119:IPR006179:IPR 006146; KEGG: cpo:COPRO5265_0800 multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-Nucleotidase domain protein; metallophosphoesterase; S-layer domain protein; PRIAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase., 5'-nucleotidase; SPTR: Multifunctional protein: 5-nucleotidase 2,3-cyclic-nucleotide 2-phosphodiesterase; PFAM: 5'-nucleotidase, C-termin [...] | 0.468 |
| Toce_1781 | Toce_1780 | Toce_1781 | Toce_1780 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: tit:Thit_0541 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. | 0.698 |
| Toce_1781 | Toce_1782 | Toce_1781 | Toce_1782 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.944 |
| Toce_1781 | Toce_1784 | Toce_1781 | Toce_1784 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | Lipoprotein LpqB, GerMN domain protein; COGs: COG5401 Spore germination protein; InterPro IPR019606; KEGG: aoe:Clos_0556 hypothetical protein; PFAM: Lipoprotein LpqB, GerMN domain; SPTR: Putative uncharacterized protein; PFAM: Sporulation and spore germination. | 0.688 |
| Toce_1781 | Toce_1785 | Toce_1781 | Toce_1785 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | Protein of unknown function DUF2179; COGs: COG4843 conserved hypothetical protein; InterPro IPR019264; KEGG: aoe:Clos_0555 hypothetical protein; PFAM: Protein of unknown function DUF2179; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2179). | 0.572 |
| Toce_1781 | Toce_1786 | Toce_1781 | Toce_1786 | Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. | Cell wall hydrolase/autolysin; COGs: COG0860 N-acetylmuramoyl-L-alanine amidase; InterPro IPR012854:IPR002508; KEGG: tit:Thit_0595 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; copper amine oxidase domain protein; SMART: cell wall hydrolase/autolysin; SPTR: N-acetylmuramoyl-L-alanine amidase; PFAM: Copper amine oxidase N-terminal domain; N-acetylmuramoyl-L-alanine amidase; Localisation of periplasmic protein complexes; TIGRFAM: N-acetylmuramoyl-L-alanine amidase CwlD. | 0.505 |