Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Toce_1786Cell wall hydrolase/autolysin; COGs: COG0860 N-acetylmuramoyl-L-alanine amidase; InterPro IPR012854:IPR002508; KEGG: tit:Thit_0595 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; copper amine oxidase domain protein; SMART: cell wall hydrolase/autolysin; SPTR: N-acetylmuramoyl-L-alanine amidase; PFAM: Copper amine oxidase N-terminal domain; N-acetylmuramoyl-L-alanine amidase; Localisation of periplasmic protein complexes; TIGRFAM: N-acetylmuramoyl-L-alanine amidase CwlD. (534 aa)    
Predicted Functional Partners:
Toce_1795
Cell wall hydrolase/autolysin; COGs: COG0860 N-acetylmuramoyl-L-alanine amidase; InterPro IPR002508; KEGG: bmq:BMQ_0173 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; SMART: cell wall hydrolase/autolysin; SPTR: Cell wall hydrolase/autolysin; PFAM: N-acetylmuramoyl-L-alanine amidase; TIGRFAM: N-acetylmuramoyl-L-alanine amidase CwlD.
  
  
 
0.924
Toce_0619
Rhomboid family protein; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: tpd:Teth39_1878 rhomboid family protein; PFAM: Rhomboid family protein; SPTR: Rhomboid family protein; PFAM: Rhomboid family.
   
   0.817
Toce_1785
Protein of unknown function DUF2179; COGs: COG4843 conserved hypothetical protein; InterPro IPR019264; KEGG: aoe:Clos_0555 hypothetical protein; PFAM: Protein of unknown function DUF2179; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2179).
       0.620
Toce_1782
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
       0.519
rph
RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
       0.519
Toce_1781
Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR000979:IPR004843; KEGG: dae:Dtox_3620 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Phosphodiesterase, MJ0936 family; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family.
  
    0.505
Toce_0197
S-layer domain protein; InterPro IPR001119; KEGG: tit:Thit_0105 S-layer domain protein; PFAM: S-layer domain protein; SPTR: S-layer domain protein; PFAM: S-layer homology domain.
 
  
 0.496
Toce_1784
Lipoprotein LpqB, GerMN domain protein; COGs: COG5401 Spore germination protein; InterPro IPR019606; KEGG: aoe:Clos_0556 hypothetical protein; PFAM: Lipoprotein LpqB, GerMN domain; SPTR: Putative uncharacterized protein; PFAM: Sporulation and spore germination.
       0.487
rex-2
CoA-binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
       0.442
Toce_2054
Hypothetical protein; KEGG: cbr:CBG00233 C. briggsae CBR-TWK-18 protein; SPTR: Predicted protein.
    
   0.439
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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