Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Toce_1816PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063:IPR012089; KEGG: ate:Athe_0195 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; TIGRFAM: conserved hypothetical protein TIGR00269; Belongs to the TtcA family. (316 aa)    
Predicted Functional Partners:
Toce_1987
tRNA (adenine-58-N(1)-) methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
 
  
 0.841
Toce_1817
thiamineS protein; InterPro IPR003749; KEGG: tit:Thit_0461 thiamineS protein; PFAM: thiamineS protein; SPTR: ThiamineS protein; PFAM: ThiS family.
  
  
 0.770
bpsA
Protein of unknown function DUF43; Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.
  
     0.581
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
  
 0.570
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
   
 0.547
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
     
 0.543
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
    0.531
Toce_0479
tRNA pseudouridine synthase D TruD; COGs: COG0585 conserved hypothetical protein; InterPro IPR011760:IPR020119:IPR001656; KEGG: csc:Csac_1232 tRNA pseudouridine synthase D, TruD; PFAM: tRNA pseudouridine synthase D TruD; SPTR: tRNA pseudouridine synthase D, TruD; PFAM: tRNA pseudouridine synthase D (TruD); TIGRFAM: conserved hypothetical protein TIGR00094.
 
 
 0.514
Toce_0732
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: mta:Moth_1970 UBA/ThiF-type NAD/FAD binding fold; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: UBA/THIF-type NAD/FAD binding fold; PFAM: MoeZ/MoeB domain; ThiF family.
 
 
 0.484
rnr
RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
  
    0.479
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.