Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Toce_1865Protein of unknown function DUF214; COGs: COG4591 ABC-type transport system involved in lipoprotein release permease component; InterPro IPR003838; KEGG: nth:Nther_2083 protein of unknown function DUF214; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. (787 aa)    
Predicted Functional Partners:
Toce_1864
ABC transporter related protein; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003439:IPR003593:IPR017871; KEGG: nth:Nther_2084 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related; PFAM: ABC transporter.
 
 
 0.994
Toce_1866
Efflux transporter, RND family, MFP subunit; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR006143:IPR000089; KEGG: dhd:Dhaf_4678 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; biotin/lipoyl attachment domain-containing protein; SPTR: Putative uncharacterized protein; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
   
 0.946
Toce_2165
ABC transporter related protein; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003593:IPR017871:IPR003439; KEGG: aoe:Clos_2616 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related; PFAM: ABC transporter.
  
 
 0.895
macB
ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.895
Toce_2054
Hypothetical protein; KEGG: cbr:CBG00233 C. briggsae CBR-TWK-18 protein; SPTR: Predicted protein.
   
 
 0.793
Toce_2170
Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: tit:Thit_0217 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; biotin/lipoyl attachment domain-containing protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit.
 
 
 0.675
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532:IPR002547:IPR005146:IPR005147:IPR 005121; KEGG: tit:Thit_1516 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; PRIAM: Phenylalanine--tRNA ligase; SPTR: Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetases class II core domain (F); tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; [...]
     
 0.582
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.484
Toce_1863
InterPro IPR000182; KEGG: cbe:Cbei_3901 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: GCN5-related N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family.
  
    0.483
Toce_0200
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594:IPR004358:IPR005467; KEGG: bld:BLi00981 hypothetical protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
   
 
 0.400
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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