Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Toce_1893Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family. (237 aa)    
Predicted Functional Partners:
Toce_1894
Protein of unknown function UPF0079; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: amt:Amet_0803 hypothetical protein; PFAM: protein of unknown function UPF0079; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: conserved hypothetical nucleotide-binding protein.
 
 0.999
tsaD
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
 0.998
Toce_1892
COGs: COG0456 Acetyltransferase; InterPro IPR006464:IPR000182; KEGG: bmq:BMQ_0258 ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Ribosomal-protein (S18)-alanine acetyltransferase; TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: Acetyltransferase (GNAT) family; TIGRFAM: ribosomal-protein-alanine acetyltransferase.
 
 0.998
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
 
    0.939
tilS
tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
   
 0.746
Toce_2068
Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
    
 0.698
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.586
Toce_1191
Phage SPO1 DNA polymerase-related protein; COGs: COG1573 Uracil-DNA glycosylase; InterPro IPR005122:IPR005273; KEGG: aco:Amico_0876 phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily; SPTR: Uracil-DNA glycosylase; TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil DNA glycosylase superfamily; TIGRFAM: uracil-DNA glycosylase, family 4.
  
    0.584
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
   
 0.563
Toce_1895
Conserved hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
       0.520
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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