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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Toce_1898Glyoxylate reductase; COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006140:IPR006139; KEGG: tpd:Teth39_2066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; PRIAM: Glyoxylate reductase; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (320 aa)    
Predicted Functional Partners:
Toce_1604
COGs: COG0572 Uridine kinase; KEGG: amt:Amet_3643 phosphoribulokinase/uridine kinase; SPTR: Phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase / Uridine kinase family.
   
  0.805
Toce_1899
COGs: COG2055 Malate/L-lactate dehydrogenase; InterPro IPR003767; KEGG: bbe:BBR47_30890 putative malate/L-sulfolactate dehydrogenase; PFAM: Malate/L-lactate dehydrogenase; SPTR: Malate/L-lactate dehydrogenase; PFAM: Malate/L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family.
     
 0.752
Toce_1897
COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; InterPro IPR000887; KEGG: tit:Thit_0170 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; SPTR: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase.
     
 0.744
Toce_1900
PTS system sorbose subfamily IIB component; COGs: COG3444 Phosphotransferase system mannose/fructose/N-acetylgalactosamine-specific component IIB; InterPro IPR004720; KEGG: tpd:Teth39_2067 PTS system sorbose subfamily IIB component; PFAM: PTS system sorbose subfamily IIB component; SPTR: PTS system sorbose subfamily IIB component; PFAM: PTS system sorbose subfamily IIB component.
     
 0.619
Toce_1901
COGs: COG2893 Phosphotransferase system mannose/fructose-specific component IIA; InterPro IPR004701; KEGG: tit:Thit_0165 PTS system fructose subfamily IIA component; PFAM: PTS system fructose subfamily IIA component; SPTR: PTS system fructose subfamily IIA component; PFAM: PTS system fructose IIA component; TIGRFAM: PTS system, mannose/fructose/sorbose family, IIA component.
     
 0.581
rplF
LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
   0.521
Toce_1896
COGs: COG1023 6-phosphogluconate dehydrogenase; InterPro IPR006183:IPR004849:IPR006115:IPR006114; KEGG: cbk:CLL_A1312 6-phosphogluconate dehydrogenase-like protein; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; 6-phosphogluconate dehydrogenase domain protein; SPTR: 6-phosphogluconate dehydrogenase, decarboxylating; TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase; 6-phosphogluconate dehydrogenase, C-terminal domain; TIGRFAM: 6-phosphogluconate dehydrogenase (decarboxylating); 6-phosphogluconate dehydrogenase, [...]
       0.520
ispH
Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
  
  
 0.519
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.507
Toce_0853
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: tte:TTE1122 deacetylase; PFAM: histone deacetylase superfamily; SPTR: Deacetylases, including yeast histone deacetylase and acetoin utilization protein; PFAM: Histone deacetylase domain.
   
 0.486
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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