Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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Toce_1933Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR001131:IPR001714:IPR000587:IPR000994; KEGG: cbl:CLK_3532 M24 family metallopeptidase; PFAM: peptidase M24; creatinase; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. (358 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
   0.745
Toce_1934
Amino acid/polyamine/organocation transporter, APC superfamily (TC 2.A.3); COGs: COG0531 Amino acid transporter; InterPro IPR002293:IPR004841; KEGG: cbf:CLI_0414 amino acid permease family protein; PFAM: amino acid permease-associated region; SPTR: Amino acid permease family protein; PFAM: Amino acid permease.
 
  
 0.707
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.645
Toce_2243
Peptidase M1 membrane alanine aminopeptidase; COGs: COG0308 Aminopeptidase N; InterPro IPR014782; KEGG: tte:TTE2694 aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: Aminopeptidase N; PFAM: Peptidase family M1.
  
 
 0.618
Toce_1760
Dipeptidase; COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR010964:IPR002933:IPR011650:IPR001261; KEGG: tpd:Teth39_0750 dipeptidase PepV; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; TIGRFAM: dipeptidase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: dipeptidase, putative.
 
 
 0.605
aroK
3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the shikimate kinase family.
 
  
 0.535
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
  
 0.502
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.496
Toce_1675
KEGG: cbo:CBO2473 integral membrane protein; SPTR: Putative integral membrane protein; PFAM: Sulfite exporter TauE/SafE.
 
    0.496
gatA
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).
   
   0.484
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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