STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_1933Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR001131:IPR001714:IPR000587:IPR000994; KEGG: cbl:CLK_3532 M24 family metallopeptidase; PFAM: peptidase M24; creatinase; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. (358 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
   0.807
Toce_1934
Amino acid/polyamine/organocation transporter, APC superfamily (TC 2.A.3); COGs: COG0531 Amino acid transporter; InterPro IPR002293:IPR004841; KEGG: cbf:CLI_0414 amino acid permease family protein; PFAM: amino acid permease-associated region; SPTR: Amino acid permease family protein; PFAM: Amino acid permease.
 
 
 0.711
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.647
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.549
aroK
3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the shikimate kinase family.
 
    0.540
Toce_1675
KEGG: cbo:CBO2473 integral membrane protein; SPTR: Putative integral membrane protein; PFAM: Sulfite exporter TauE/SafE.
 
    0.498
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.495
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
    0.472
Toce_1683
D-proline reductase (dithiol); InterPro IPR015417; KEGG: cbl:CLK_3050 glycine/sarcosine/betaine reductase, component B, subunits alpha and beta; PFAM: Glycine/sarcosine/betaine reductase complex protein B alpha and beta subunits; PRIAM: D-proline reductase (dithiol); SPTR: Glycine/sarcosine/betaine reductase, component B, subunits alpha and beta; PFAM: Glycine/sarcosine/betaine reductase component B subunits.
  
     0.434
Toce_1678
D-proline reductase (dithiol); InterPro IPR015417; KEGG: cbl:CLK_1856 PrdE protein; PFAM: Glycine/sarcosine/betaine reductase complex protein B alpha and beta subunits; PRIAM: D-proline reductase (dithiol); SPTR: D-proline reductase (Dithiol); PFAM: Glycine/sarcosine/betaine reductase component B subunits.
 
     0.433
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.