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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_1935COGs: COG5015 conserved hypothetical protein; InterPro IPR011576; KEGG: drm:Dred_0307 pyridoxamine 5'-phosphate oxidase-related, FMN-binding; PFAM: pyridoxamine 5'-phosphate oxidase-related FMN-binding; SPTR: Pyridoxamine 5'-phosphate oxidase-related, FMN-binding; PFAM: Pyridoxamine 5'-phosphate oxidase. (135 aa)    
Predicted Functional Partners:
Toce_1961
COGs: COG1733 transcriptional regulator protein; InterPro IPR002577; KEGG: cbe:Cbei_3315 HxlR family transcriptional regulator; PFAM: helix-turn-helix HxlR type; SPTR: Transcriptional regulator, HxlR family; PFAM: HxlR-like helix-turn-helix.
 
     0.499
Toce_1936
AMP-dependent synthetase and ligase; COGs: COG1541 Coenzyme F390 synthetase; InterPro IPR000873; KEGG: tit:Thit_0986 coenzyme F390 synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: Coenzyme F390 synthetase; PFAM: AMP-binding enzyme.
       0.452
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.422
Toce_1934
Amino acid/polyamine/organocation transporter, APC superfamily (TC 2.A.3); COGs: COG0531 Amino acid transporter; InterPro IPR002293:IPR004841; KEGG: cbf:CLI_0414 amino acid permease family protein; PFAM: amino acid permease-associated region; SPTR: Amino acid permease family protein; PFAM: Amino acid permease.
       0.410
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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