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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_2033GAF modulated sigma54 specific transcriptional regulator, Fis family; COGs: COG3284 Transcriptional activator of acetoin/glycerol metabolism; InterProIPR000014:IPR003593:IPR002078:IPR020441:IPR 003018:IPR013767:IPR002197; KEGG: tex:Teth514_2035 fis family GAF modulated sigma54 specific transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; GAF domain protein; PAS fold domain protein; helix-turn-helix Fis-type; SMART: AAA ATPase; PAS domain containing protein; SPTR: GAF modulated sigma54 specific transcriptional regulator, Fis family; PFAM: Bacterial reg [...] (654 aa)    
Predicted Functional Partners:
Toce_1856
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: pth:PTH_2724 DNA-directed RNA polymerase specialized sigma subunit, sigma54-like protein; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; Sigma-54 factor, core binding domain; TIGRFAM: RNA polymeras [...]
 
  
 0.806
Toce_2029
ATP-NAD/AcoX kinase; COGs: COG3199 conserved hypothetical protein; InterPro IPR011391:IPR002504; KEGG: tpd:Teth39_0792 ATP-NAD/AcoX kinase; PFAM: ATP-NAD/AcoX kinase; SPTR: ATP-NAD/AcoX kinase; PFAM: ATP-NAD kinase.
 
   
 0.586
Toce_2032
Conserved hypothetical protein; InterPro IPR011719; KEGG: tpd:Teth39_0789 hypothetical protein; PFAM: conserved hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Conserved hypothetical protein (Lin0512_fam); TIGRFAM: conserved hypothetical protein.
 
     0.540
Toce_2030
Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: tex:Teth514_2032 transketolase, central region; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Transketolase, pyridine binding domain protein; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
     
 0.525
pdhA-2
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.517
Toce_2028
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR003016:IPR000089:IPR004167:IPR001078; KEGG: tex:Teth514_2030 dehydrogenase catalytic domain-containing protein; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 [...]
  
  
 0.467
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.418
rbsA
Monosaccharide ABC transporter ATP-binding protein, CUT2 family; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
   
  
 0.407
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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