| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_1893 | Toce_1894 | Toce_1893 | Toce_1894 | Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family. | Protein of unknown function UPF0079; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: amt:Amet_0803 hypothetical protein; PFAM: protein of unknown function UPF0079; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: conserved hypothetical nucleotide-binding protein. | 0.999 |
| Toce_1893 | Toce_2068 | Toce_1893 | Toce_2068 | Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.698 |
| Toce_1893 | tsaD | Toce_1893 | Toce_1891 | Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.998 |
| Toce_1894 | Toce_1893 | Toce_1894 | Toce_1893 | Protein of unknown function UPF0079; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: amt:Amet_0803 hypothetical protein; PFAM: protein of unknown function UPF0079; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: conserved hypothetical nucleotide-binding protein. | Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family. | 0.999 |
| Toce_1894 | Toce_2068 | Toce_1894 | Toce_2068 | Protein of unknown function UPF0079; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: amt:Amet_0803 hypothetical protein; PFAM: protein of unknown function UPF0079; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: conserved hypothetical nucleotide-binding protein. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.780 |
| Toce_1894 | tsaD | Toce_1894 | Toce_1891 | Protein of unknown function UPF0079; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: amt:Amet_0803 hypothetical protein; PFAM: protein of unknown function UPF0079; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: conserved hypothetical nucleotide-binding protein. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.998 |
| Toce_2066 | Toce_2067 | Toce_2066 | Toce_2067 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | 0.963 |
| Toce_2066 | Toce_2068 | Toce_2066 | Toce_2068 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.722 |
| Toce_2066 | Toce_2073 | Toce_2066 | Toce_2073 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Protein of unknown function DUF1385; COGs: COG3872 metal-dependent protein; InterPro IPR010787; KEGG: nth:Nther_2873 protein of unknown function DUF1385; PFAM: protein of unknown function DUF1385; SPTR: Putative lipoprotein; PFAM: Protein of unknown function (DUF1385). | 0.604 |
| Toce_2066 | glyA | Toce_2066 | Toce_2065 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
| Toce_2066 | prfA | Toce_2066 | Toce_2072 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.604 |
| Toce_2066 | prmC | Toce_2066 | Toce_2071 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.725 |
| Toce_2067 | Toce_2066 | Toce_2067 | Toce_2066 | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | 0.963 |
| Toce_2067 | Toce_2068 | Toce_2067 | Toce_2068 | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.979 |
| Toce_2067 | Toce_2073 | Toce_2067 | Toce_2073 | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | Protein of unknown function DUF1385; COGs: COG3872 metal-dependent protein; InterPro IPR010787; KEGG: nth:Nther_2873 protein of unknown function DUF1385; PFAM: protein of unknown function DUF1385; SPTR: Putative lipoprotein; PFAM: Protein of unknown function (DUF1385). | 0.697 |
| Toce_2067 | glyA | Toce_2067 | Toce_2065 | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
| Toce_2067 | prfA | Toce_2067 | Toce_2072 | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.703 |
| Toce_2067 | prmC | Toce_2067 | Toce_2071 | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.698 |
| Toce_2068 | Toce_1893 | Toce_2068 | Toce_1893 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: cth:Cthe_1775 peptidase M22, glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Putative uncharacterized protein; PFAM: Glycoprotease family. | 0.698 |
| Toce_2068 | Toce_1894 | Toce_2068 | Toce_1894 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Protein of unknown function UPF0079; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: amt:Amet_0803 hypothetical protein; PFAM: protein of unknown function UPF0079; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: conserved hypothetical nucleotide-binding protein. | 0.780 |