| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_2063 | Toce_2066 | Toce_2063 | Toce_2066 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | 0.815 |
| Toce_2063 | Toce_2067 | Toce_2063 | Toce_2067 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | 0.720 |
| Toce_2063 | Toce_2068 | Toce_2063 | Toce_2068 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.691 |
| Toce_2063 | Toce_2069 | Toce_2063 | Toce_2069 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | COGs: COG2059 Chromate transport protein ChrA; InterPro IPR003370; KEGG: tex:Teth514_2360 chromate transporter; PFAM: Chromate transporter; SPTR: Chromate transporter; PFAM: Chromate transporter. | 0.487 |
| Toce_2063 | Toce_2070 | Toce_2063 | Toce_2070 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | COGs: COG2059 Chromate transport protein ChrA; InterPro IPR003370; KEGG: tit:Thit_2330 chromate transporter; PFAM: Chromate transporter; SPTR: Chromate transporter; manually curated; PFAM: Chromate transporter. | 0.487 |
| Toce_2063 | Toce_2073 | Toce_2063 | Toce_2073 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Protein of unknown function DUF1385; COGs: COG3872 metal-dependent protein; InterPro IPR010787; KEGG: nth:Nther_2873 protein of unknown function DUF1385; PFAM: protein of unknown function DUF1385; SPTR: Putative lipoprotein; PFAM: Protein of unknown function (DUF1385). | 0.647 |
| Toce_2063 | glyA | Toce_2063 | Toce_2065 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.869 |
| Toce_2063 | prfA | Toce_2063 | Toce_2072 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.655 |
| Toce_2063 | prmC | Toce_2063 | Toce_2071 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.650 |
| Toce_2063 | rpmE | Toce_2063 | Toce_2074 | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | LSU ribosomal protein L31P; Binds the 23S rRNA. | 0.520 |
| Toce_2066 | Toce_2063 | Toce_2066 | Toce_2063 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR013838:IPR016192:IPR016473:IPR002125; KEGG: pth:PTH_2823 deoxycytidylate deaminase; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Deoxycytidylate deaminase; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. | 0.815 |
| Toce_2066 | Toce_2067 | Toce_2066 | Toce_2067 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR017867:IPR000106; KEGG: dae:Dtox_4179 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein tyrosine phosphatase; PFAM: Low molecular weight phosphotyrosine protein phosphatase. | 0.969 |
| Toce_2066 | Toce_2068 | Toce_2066 | Toce_2068 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.766 |
| Toce_2066 | Toce_2069 | Toce_2066 | Toce_2069 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | COGs: COG2059 Chromate transport protein ChrA; InterPro IPR003370; KEGG: tex:Teth514_2360 chromate transporter; PFAM: Chromate transporter; SPTR: Chromate transporter; PFAM: Chromate transporter. | 0.511 |
| Toce_2066 | Toce_2070 | Toce_2066 | Toce_2070 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | COGs: COG2059 Chromate transport protein ChrA; InterPro IPR003370; KEGG: tit:Thit_2330 chromate transporter; PFAM: Chromate transporter; SPTR: Chromate transporter; manually curated; PFAM: Chromate transporter. | 0.511 |
| Toce_2066 | Toce_2073 | Toce_2066 | Toce_2073 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Protein of unknown function DUF1385; COGs: COG3872 metal-dependent protein; InterPro IPR010787; KEGG: nth:Nther_2873 protein of unknown function DUF1385; PFAM: protein of unknown function DUF1385; SPTR: Putative lipoprotein; PFAM: Protein of unknown function (DUF1385). | 0.666 |
| Toce_2066 | glyA | Toce_2066 | Toce_2065 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
| Toce_2066 | prfA | Toce_2066 | Toce_2072 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.666 |
| Toce_2066 | prmC | Toce_2066 | Toce_2071 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.769 |
| Toce_2066 | rpmE | Toce_2066 | Toce_2074 | COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family. | LSU ribosomal protein L31P; Binds the 23S rRNA. | 0.604 |