STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (449 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
  
 0.891
Toce_2123
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR003593:IPR018368:IPR001270:IPR004176:IPR 003959:IPR001943:IPR013093:IPR019489; KEGG: tte:TTE2327 ATPase with chaperone activity, ATP-binding subunit; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATPases with chaperone activity, ATP-binding subunit; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associat [...]
  
  
 0.808
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
  
    0.806
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.805
Toce_2125
UvrB/UvrC protein; COGs: COG3880 Uncharacterized protein with conserved CXXC pairs; InterPro IPR001943; KEGG: tit:Thit_2016 UvrB/UvrC protein; PFAM: UvrB/UvrC protein; SPTR: UvrB/UvrC protein; PFAM: UvrB/uvrC motif.
  
    0.764
Toce_1758
COGs: COG0210 Superfamily I DNA and RNA helicase; InterProIPR005751:IPR000212:IPR014016:IPR014017:IPR 005829; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; SPTR: ATP-dependent DNA helicase PcrA; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; ATP-dependent DNA helicase PcrA.
   
  
 0.740
Toce_2126
COGs: COG4463 Transcriptional repressor of class III stress genes; InterPro IPR008463; KEGG: chy:CHY_2351 transcriptional regulator CtsR; PFAM: Firmicute transcriptional repressor of class III stress genes; SPTR: Transcriptional regulator CtsR; PFAM: Firmicute transcriptional repressor of class III stress genes (CtsR); Belongs to the CtsR family.
  
  
 0.725
Toce_2119
COGs: COG4956 Integral membrane protein (PIN domain superfamily); InterPro IPR006596:IPR002716:IPR002792; KEGG: tpd:Teth39_0345 PilT domain-containing protein; PFAM: PilT protein domain protein; SMART: Nucleotide binding protein PINc; SPTR: PilT protein domain protein; PFAM: TRAM domain; PIN domain.
  
  
 0.681
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
  
  
 0.593
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.578
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.