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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Toce_2133Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (772 aa)    
Predicted Functional Partners:
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.948
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
 0.926
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR008243:IPR000623:IPR011994:IPR003136; KEGG: tit:Thit_1145 cytidylate kinase; PFAM: cytidylate kinase region; Chorismate mutase of the AroH class; shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: cytidylate kinase; chorismate mutase; PFAM: Cytidylate kinase; Chorismate mutase type I; TIGRFAM: cytidylate kinase; monofunctional chorismate mutase, gram positive type, clade 1.
  
 
 0.925
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.919
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.916
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.908
Toce_1364
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.902
Toce_0060
Thioredoxin; COGs: COG3118 Thioredoxin domain-containing protein; InterProIPR005746:IPR013766:IPR006662:IPR017937:IPR 017936; KEGG: rmr:Rmar_0180 thioredoxin; PFAM: Thioredoxin domain; SPTR: Thioredoxin; TIGRFAM: thioredoxin; PFAM: Thioredoxin; TIGRFAM: thioredoxin; Belongs to the thioredoxin family.
  
 
 0.798
Toce_1622
COGs: COG3118 Thioredoxin domain-containing protein; InterPro IPR013766:IPR017936; KEGG: tte:TTE1880 thiol-disulfide isomerase and thioredoxins; PFAM: Thioredoxin domain; SPTR: Thiol-disulfide isomerase and thioredoxins; PFAM: Thioredoxin; TIGRFAM: thioredoxin; Belongs to the thioredoxin family.
  
 
 0.798
Toce_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.765
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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