| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_0615 | macB | Toce_0615 | Toce_2171 | COGs: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; InterPro IPR000515; KEGG: sth:STH130 oligopeptide ABC transporter permease protein; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: Oligopeptide ABC transporter permease protein; PFAM: Binding-protein-dependent transport system inner membrane component. | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.825 |
| Toce_0660 | macB | Toce_0660 | Toce_2171 | COGs: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems permease components; InterPro IPR000515; KEGG: tex:Teth514_0548 binding-protein-dependent transport systems inner membrane component; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: Binding-protein-dependent transport systems inner membrane component; PFAM: Binding-protein-dependent transport system inner membrane component. | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.710 |
| Toce_1571 | macB | Toce_1571 | Toce_2171 | Amino acid ABC transporter membrane protein, PAAT family; COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR010065:IPR000515; KEGG: tex:Teth514_0469 polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: Polar amino acid ABC transporter, inner membrane subunit; TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease protein, 3-TM region, Hi [...] | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.867 |
| Toce_1865 | Toce_2170 | Toce_1865 | Toce_2170 | Protein of unknown function DUF214; COGs: COG4591 ABC-type transport system involved in lipoprotein release permease component; InterPro IPR003838; KEGG: nth:Nther_2083 protein of unknown function DUF214; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: tit:Thit_0217 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; biotin/lipoyl attachment domain-containing protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit. | 0.675 |
| Toce_1865 | macB | Toce_1865 | Toce_2171 | Protein of unknown function DUF214; COGs: COG4591 ABC-type transport system involved in lipoprotein release permease component; InterPro IPR003838; KEGG: nth:Nther_2083 protein of unknown function DUF214; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.895 |
| Toce_2163 | Toce_2164 | Toce_2163 | Toce_2164 | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.978 |
| Toce_2163 | Toce_2167 | Toce_2163 | Toce_2167 | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein. | 0.697 |
| Toce_2163 | Toce_2169 | Toce_2163 | Toce_2169 | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | Efflux transporter, RND family, MFP subunit; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR003997:IPR006143; KEGG: mta:Moth_2370 secretion protein HlyD; PFAM: secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.853 |
| Toce_2163 | Toce_2170 | Toce_2163 | Toce_2170 | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: tit:Thit_0217 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; biotin/lipoyl attachment domain-containing protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit. | 0.991 |
| Toce_2163 | macB | Toce_2163 | Toce_2171 | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.996 |
| Toce_2164 | Toce_2163 | Toce_2164 | Toce_2163 | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | 0.978 |
| Toce_2164 | Toce_2167 | Toce_2164 | Toce_2167 | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein. | 0.964 |
| Toce_2164 | Toce_2169 | Toce_2164 | Toce_2169 | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Efflux transporter, RND family, MFP subunit; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR003997:IPR006143; KEGG: mta:Moth_2370 secretion protein HlyD; PFAM: secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.562 |
| Toce_2164 | Toce_2170 | Toce_2164 | Toce_2170 | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: tit:Thit_0217 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; biotin/lipoyl attachment domain-containing protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit. | 0.509 |
| Toce_2164 | Toce_2172 | Toce_2164 | Toce_2172 | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: tit:Thit_0219 protein of unknown function DUF214; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | 0.948 |
| Toce_2164 | macB | Toce_2164 | Toce_2171 | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.812 |
| Toce_2167 | Toce_2163 | Toce_2167 | Toce_2163 | COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein. | Protein of unknown function DUF214; COGs: COG0577 ABC-type antimicrobial peptide transport system permease component; InterPro IPR003838; KEGG: aoe:Clos_2614 hypothetical protein; PFAM: protein of unknown function DUF214; SPTR: Putative uncharacterized protein; PFAM: Predicted permease. | 0.697 |
| Toce_2167 | Toce_2164 | Toce_2167 | Toce_2164 | COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein. | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: aoe:Clos_2615 RND family efflux transporter MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein; secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.964 |
| Toce_2167 | Toce_2169 | Toce_2167 | Toce_2169 | COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein. | Efflux transporter, RND family, MFP subunit; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR003997:IPR006143; KEGG: mta:Moth_2370 secretion protein HlyD; PFAM: secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.986 |
| Toce_2167 | Toce_2170 | Toce_2167 | Toce_2170 | COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein. | Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR003997:IPR006143:IPR000089; KEGG: tit:Thit_0217 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; biotin/lipoyl attachment domain-containing protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit. | 0.994 |