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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_2177Signal peptide peptidase A; COGs: COG0616 Periplasmic serine protease (ClpP class); InterPro IPR001907:IPR004635:IPR002142; KEGG: hmo:HM1_1071 signal peptide peptidase SppA, 36k type; PFAM: peptidase S49; SPTR: Signal peptide peptidase sppa, 36k type; TIGRFAM: signal peptide peptidase SppA, 36K type; PFAM: Peptidase family S49; TIGRFAM: signal peptide peptidase SppA, 36K type. (307 aa)    
Predicted Functional Partners:
Toce_2176
KEGG: tit:Thit_0724 protein of unknown function DUF2143; SPTR: Putative uncharacterized protein; PFAM: Yip1 domain.
       0.808
Toce_2178
InterPro IPR002934; KEGG: gur:Gura_2470 DNA polymerase beta subunit; PFAM: DNA polymerase beta domain protein region; SPTR: DNA polymerase, beta domain protein region; PFAM: Nucleotidyltransferase domain.
       0.773
Toce_2179
Peptidase S16 lon domain protein; COGs: COG1067 ATP-dependent protease; InterPro IPR001984; KEGG: hor:Hore_03380 peptidase S16 lon domain protein; SPTR: Peptidase S16 lon domain protein; PFAM: Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: lon-related putative ATP-dependent protease.
  
  
 0.735
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.564
Toce_1394
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR004013:IPR002054:IPR003583:IPR003141:IPR 002008; KEGG: gbm:Gbem_0265 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; SPTR: PHP domain protein; PFAM: PHP domain.
 
     0.498
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR008243:IPR000623:IPR011994:IPR003136; KEGG: tit:Thit_1145 cytidylate kinase; PFAM: cytidylate kinase region; Chorismate mutase of the AroH class; shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: cytidylate kinase; chorismate mutase; PFAM: Cytidylate kinase; Chorismate mutase type I; TIGRFAM: cytidylate kinase; monofunctional chorismate mutase, gram positive type, clade 1.
 
     0.489
Toce_2180
KEGG: dhd:Dhaf_1776 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.471
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.426
Toce_1110
COGs: COG1776 Chemotaxis protein CheC inhibitor of MCP methylation; InterPro IPR001172:IPR007597:IPR001543:IPR012826; KEGG: tte:TTE1429 flagellar motor switch protein; PFAM: surface presentation of antigens (SPOA) protein; CheC domain protein; SPTR: Chemotaxis protein CheC, inhibitor of MCP methylation; TIGRFAM: flagellar motor switch protein FliN; PFAM: Surface presentation of antigens (SPOA); CheC-like family; TIGRFAM: flagellar motor switch protein FliN.
     
 0.425
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
       0.422
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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