| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_0960 | Toce_0964 | Toce_0960 | Toce_0964 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | 0.883 |
| Toce_0960 | Toce_0980 | Toce_0960 | Toce_0980 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.829 |
| Toce_0960 | Toce_1322 | Toce_0960 | Toce_1322 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Stage III sporulation protein AA; COGs: COG3854 conserved hypothetical protein; InterPro IPR014217:IPR003593; KEGG: tpd:Teth39_1088 AAA ATPase; SMART: AAA ATPase; SPTR: AAA ATPase; TIGRFAM: stage III sporulation protein AA; TIGRFAM: stage III sporulation protein AA. | 0.866 |
| Toce_0960 | Toce_2013 | Toce_0960 | Toce_2013 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | InterPro IPR018356:IPR014208; KEGG: hor:Hore_17740 sporulation stage III transcriptional regulator SpoIIID; SPTR: Sporulation stage III transcriptional regulator SpoIIID; TIGRFAM: sporulation transcriptional regulator SpoIIID; PFAM: Stage III sporulation protein D; TIGRFAM: sporulation transcriptional regulator SpoIIID. | 0.852 |
| Toce_0960 | Toce_2099 | Toce_0960 | Toce_2099 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932:IPR006162:IPR014221:IPR010822; KEGG: cce:Ccel_2986 stage II sporulation protein E, protein serine/threonine phosphatase; PFAM: Stage II sporulation E family protein; PRIAM: Phosphoprotein phosphatase; SMART: protein phosphatase 2C domain protein; SPTR: Stage II sporulation protein E, protein serine/threonine phosphatase; TIGRFAM: stage II sporulation protein E; manually curated; PFAM: Stage II sporulation protein E (SpoIIE); TIGRFAM: stage II sporulation protein E. | 0.965 |
| Toce_0960 | Toce_2201 | Toce_0960 | Toce_2201 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Stage II sporulation protein R; InterPro IPR014202; KEGG: tex:Teth514_0606 hypothetical protein; PFAM: Sporulation stage II protein R; SPTR: Stage II sporulation protein R; TIGRFAM: stage II sporulation protein R; PFAM: Stage II sporulation protein R (spore_II_R); TIGRFAM: stage II sporulation protein R. | 0.928 |
| Toce_0960 | Toce_2202 | Toce_0960 | Toce_2202 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | InterPro IPR008844; KEGG: tit:Thit_2221 germination protein, Ger(X)C family; PFAM: spore germination B3 GerAC family protein; SPTR: Germination protein, Ger(X)C family; TIGRFAM: germination protein, Ger(x)C family; PFAM: Spore germination B3/ GerAC like, C-terminal; TIGRFAM: germination protein, Ger(x)C family. | 0.709 |
| Toce_0960 | Toce_2203 | Toce_0960 | Toce_2203 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Spore germination protein; InterPro IPR004761; KEGG: tit:Thit_2222 spore germination protein; PFAM: Spore germination protein; SPTR: Spore germination protein; TIGRFAM: spore germination protein; PFAM: Spore germination protein; TIGRFAM: spore germination protein (amino acid permease). | 0.736 |
| Toce_0960 | Toce_2204 | Toce_0960 | Toce_2204 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | InterPro IPR004995; KEGG: tit:Thit_2223 GerA spore germination protein; PFAM: GerA spore germination protein; SPTR: GerA spore germination protein; PFAM: Bacillus/Clostridium GerA spore germination protein. | 0.688 |
| Toce_0960 | spoIIAB | Toce_0960 | Toce_1268 | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.909 |
| Toce_0964 | Toce_0960 | Toce_0964 | Toce_0960 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | sigma-E processing peptidase SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. | 0.883 |
| Toce_0964 | Toce_0980 | Toce_0964 | Toce_0980 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. | 0.811 |
| Toce_0964 | Toce_1322 | Toce_0964 | Toce_1322 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | Stage III sporulation protein AA; COGs: COG3854 conserved hypothetical protein; InterPro IPR014217:IPR003593; KEGG: tpd:Teth39_1088 AAA ATPase; SMART: AAA ATPase; SPTR: AAA ATPase; TIGRFAM: stage III sporulation protein AA; TIGRFAM: stage III sporulation protein AA. | 0.776 |
| Toce_0964 | Toce_2013 | Toce_0964 | Toce_2013 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | InterPro IPR018356:IPR014208; KEGG: hor:Hore_17740 sporulation stage III transcriptional regulator SpoIIID; SPTR: Sporulation stage III transcriptional regulator SpoIIID; TIGRFAM: sporulation transcriptional regulator SpoIIID; PFAM: Stage III sporulation protein D; TIGRFAM: sporulation transcriptional regulator SpoIIID. | 0.770 |
| Toce_0964 | Toce_2099 | Toce_0964 | Toce_2099 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001932:IPR006162:IPR014221:IPR010822; KEGG: cce:Ccel_2986 stage II sporulation protein E, protein serine/threonine phosphatase; PFAM: Stage II sporulation E family protein; PRIAM: Phosphoprotein phosphatase; SMART: protein phosphatase 2C domain protein; SPTR: Stage II sporulation protein E, protein serine/threonine phosphatase; TIGRFAM: stage II sporulation protein E; manually curated; PFAM: Stage II sporulation protein E (SpoIIE); TIGRFAM: stage II sporulation protein E. | 0.752 |
| Toce_0964 | Toce_2201 | Toce_0964 | Toce_2201 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | Stage II sporulation protein R; InterPro IPR014202; KEGG: tex:Teth514_0606 hypothetical protein; PFAM: Sporulation stage II protein R; SPTR: Stage II sporulation protein R; TIGRFAM: stage II sporulation protein R; PFAM: Stage II sporulation protein R (spore_II_R); TIGRFAM: stage II sporulation protein R. | 0.891 |
| Toce_0964 | Toce_2202 | Toce_0964 | Toce_2202 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | InterPro IPR008844; KEGG: tit:Thit_2221 germination protein, Ger(X)C family; PFAM: spore germination B3 GerAC family protein; SPTR: Germination protein, Ger(X)C family; TIGRFAM: germination protein, Ger(x)C family; PFAM: Spore germination B3/ GerAC like, C-terminal; TIGRFAM: germination protein, Ger(x)C family. | 0.406 |
| Toce_0964 | Toce_2203 | Toce_0964 | Toce_2203 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | Spore germination protein; InterPro IPR004761; KEGG: tit:Thit_2222 spore germination protein; PFAM: Spore germination protein; SPTR: Spore germination protein; TIGRFAM: spore germination protein; PFAM: Spore germination protein; TIGRFAM: spore germination protein (amino acid permease). | 0.450 |
| Toce_0964 | Toce_2204 | Toce_0964 | Toce_2204 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | InterPro IPR004995; KEGG: tit:Thit_2223 GerA spore germination protein; PFAM: GerA spore germination protein; SPTR: GerA spore germination protein; PFAM: Bacillus/Clostridium GerA spore germination protein. | 0.752 |
| Toce_0964 | spoIIAB | Toce_0964 | Toce_1268 | Sporulation protein, YlmC/YmxH family; COGs: COG1873 conserved hypothetical protein; InterPro IPR007903:IPR014238; KEGG: csc:Csac_1196 PRC-barrel domain-containing protein; PFAM: PRC-barrel domain protein; SPTR: PRC-barrel domain protein; TIGRFAM: sporulation protein, YlmC/YmxH family; PFAM: PRC-barrel domain; TIGRFAM: sporulation protein, YlmC/YmxH family. | Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.719 |