close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_2249HI0933 family protein; COGs: COG2509 Uncharacterized FAD-dependent dehydrogenase; InterPro IPR004792; KEGG: tit:Thit_2322 FAD dependent oxidoreductase; PFAM: HI0933 family protein; SPTR: FAD dependent oxidoreductase; PFAM: HI0933-like protein. (466 aa)    
Predicted Functional Partners:
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
       0.844
rplI
LSU ribosomal protein L9P; Binds to the 23S rRNA.
       0.493
Toce_2251
Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
       0.492
Toce_2254
COGs: COG4241 membrane protein; InterPro IPR018710; KEGG: aco:Amico_1419 protein of unknown function DUF2232, membrane; PFAM: Protein of unknown function DUF2232, membrane; SPTR: Membrane protein-like; PFAM: Predicted membrane protein (DUF2232).
       0.432
Toce_2250
Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR018335:IPR000595:IPR012318:IPR001808; KEGG: aoe:Clos_2132 Crp/FNR family transcriptional regulator; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain.
       0.427
Toce_2253
COGs: COG3887 signaling protein consisting of a modified GGDEF domain and a DHH domain; InterPro IPR000160:IPR001667:IPR003156; KEGG: aoe:Clos_2799 phosphoesterase domain-containing protein; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SPTR: Phosphoesterase RecJ domain protein; PFAM: DHH family; DHHA1 domain.
       0.418
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
       0.412
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.