Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
Toce_2269KEGG: cbl:CLK_3121 hypothetical protein; SPTR: Putative uncharacterized protein. (180 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.778
scpA
Chromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
  
 
 0.756
Toce_2270
Protein of unknown function DUF554; COGs: COG1811 Uncharacterized membrane protein possible Na+ channel or pump; InterPro IPR007563; KEGG: dhd:Dhaf_4952 protein of unknown function DUF554; PFAM: protein of unknown function DUF554; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF554).
       0.755
Toce_2268
Peptidase M23; COGs: COG0739 Membrane protein related to metalloendopeptidase; InterPro IPR016047; KEGG: tte:TTE0841 membrane proteins related to metalloendopeptidase; PFAM: Peptidase M23; SPTR: M23 peptidase domain protein; PFAM: Peptidase family M23.
       0.675
Toce_2271
Cysteine desulfurase family protein; COGs: COG0520 Selenocysteine lyase; InterPro IPR010969:IPR000192; KEGG: tte:TTE2789 selenocysteine lyase; PFAM: aminotransferase class V; SPTR: Selenocysteine lyase; TIGRFAM: cysteine desulfurase family protein; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase family protein.
     
 0.668
Toce_2267
Protein of unknown function DUF583; COGs: COG1664 Integral membrane protein CcmA involved in cell shape determination; InterPro IPR007607; KEGG: tit:Thit_0787 protein of unknown function DUF583; PFAM: protein of unknown function DUF583; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function, DUF583.
       0.666
Toce_2266
Diacylglycerol kinase catalytic region; COGs: COG1597 Sphingosine kinase; InterPro IPR001206:IPR005218; KEGG: diacylglycerol kinase catalytic region; PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region; SPTR: Diacylglycerol kinase catalytic region; PFAM: Diacylglycerol kinase catalytic domain; TIGRFAM: conserved protein of unknown function cotranscribed with Bmr (bmrU).
 
     0.607
Toce_1679
D-proline reductase (dithiol); KEGG: cbf:CLI_3802 glycine/sarcosine/betaine reductase, component B, subunits alpha and beta; PRIAM: D-proline reductase (dithiol); SPTR: Glycine/sarcosine/betaine reductase, component B, subunits alpha and beta; PFAM: Glycine/sarcosine/betaine reductase component B subunits.
   
 
 0.587
Toce_1588
COGs: COG0438 Glycosyltransferase; InterProIPR001296:IPR013216:IPR001173:IPR019734:IPR 013026:IPR000276; KEGG: tnp:Tnap_0554 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; Methyltransferase type 11; glycosyl transferase group 1; SMART: Tetratricopeptide repeat; SPTR: Glycosyl transferase family 2; PFAM: Methyltransferase domain; Glycosyl transferases group 1; Glycosyl transferase family 2.
  
 
 0.558
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.557
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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