STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EKF55158.1COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (458 aa)    
Predicted Functional Partners:
EKF55108.1
COG2176 DNA polymerase III, alpha subunit (gram-positive type).
    
 0.940
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.898
EKF56272.1
COG0587 DNA polymerase III, alpha subunit.
 
  
 0.839
EKF56042.1
COG1466 DNA polymerase III, delta subunit.
    
 0.818
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
 
 0.818
EKF55625.1
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.810
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
     
 0.783
EKF54677.1
Exonuclease; COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.
 
  
0.778
EKF55658.1
Exonuclease; COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.
  
  
 
0.765
EKF56764.1
DNA polymerase III subunit delta; COG0470 ATPase involved in DNA replication.
   
 
 0.745
Your Current Organism:
Galbibacter marinus
NCBI taxonomy Id: 555500
Other names: CCTCC AB 209062, G. marinus, Galbibacter marinus Li et al. 2013, Galbibacter sp. ck-I2-15, LMG 25228, LMG:25228, MCCC 1A03044, strain ck-I2-15
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