node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDI09299.1 | glyA | SAMN04487993_10013 | SAMN04487993_100284 | Phosphoserine phosphatase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
SDI15817.1 | SDJ25562.1 | SAMN04487993_1001323 | SAMN04487993_102355 | Aminomethyltransferase. | Glutamate synthase (NADPH) large subunit. | 0.921 |
SDI15817.1 | folD | SAMN04487993_1001323 | SAMN04487993_102460 | Aminomethyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
SDI15817.1 | gcvH | SAMN04487993_1001323 | SAMN04487993_1001322 | Aminomethyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
SDI15817.1 | gcvP | SAMN04487993_1001323 | SAMN04487993_1001321 | Aminomethyltransferase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
SDI15817.1 | glyA | SAMN04487993_1001323 | SAMN04487993_100284 | Aminomethyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
SDI15817.1 | purH | SAMN04487993_1001323 | SAMN04487993_1002105 | Aminomethyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.906 |
SDI15817.1 | purN | SAMN04487993_1001323 | SAMN04487993_101391 | Aminomethyltransferase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.898 |
SDI61727.1 | SDJ22680.1 | SAMN04487993_1007123 | SAMN04487993_102272 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.732 |
SDI61727.1 | SDJ25562.1 | SAMN04487993_1007123 | SAMN04487993_102355 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glutamate synthase (NADPH) large subunit. | 0.952 |
SDI61727.1 | folD | SAMN04487993_1007123 | SAMN04487993_102460 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.773 |
SDI61727.1 | gcvH | SAMN04487993_1007123 | SAMN04487993_1001322 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.991 |
SDI61727.1 | gcvP | SAMN04487993_1007123 | SAMN04487993_1001321 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
SDI61727.1 | glyA | SAMN04487993_1007123 | SAMN04487993_100284 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.893 |
SDI61727.1 | purH | SAMN04487993_1007123 | SAMN04487993_1002105 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.525 |
SDI61727.1 | purN | SAMN04487993_1007123 | SAMN04487993_101391 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.460 |
SDJ22680.1 | SDI61727.1 | SAMN04487993_102272 | SAMN04487993_1007123 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.732 |
SDJ22680.1 | SDJ25562.1 | SAMN04487993_102272 | SAMN04487993_102355 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glutamate synthase (NADPH) large subunit. | 0.952 |
SDJ22680.1 | folD | SAMN04487993_102272 | SAMN04487993_102460 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.773 |
SDJ22680.1 | gcvH | SAMN04487993_102272 | SAMN04487993_1001322 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.992 |