STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACX96478.1PFAM: isochorismatase hydrolase; KEGG: vfm:VFMJ11_A0729 isochorismatase hydrolase. (173 aa)    
Predicted Functional Partners:
ACX96479.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
    0.625
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.528
ACX95695.1
PFAM: isochorismatase hydrolase; KEGG: mex:Mext_1705 isochorismatase hydrolase.
  
     0.527
ACX95693.1
PFAM: isochorismatase hydrolase; KEGG: bxe:Bxe_B1373 isochorismatase family protein.
  
     0.503
nnrE
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
   
    0.491
ACX96480.1
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: bmr:BMI_I1921 glyoxalase family protein.
  
    0.456
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.433
ACX95796.1
PFAM: KR domain protein; Beta-ketoacyl synthase; Alcohol dehydrogenase GroES domain protein; short-chain dehydrogenase/reductase SDR; Acyl transferase; Alcohol dehydrogenase zinc-binding domain protein; phosphopantetheine-binding; NAD-dependent epimerase/dehydratase; KEGG: npu:Npun_F3360 beta-ketoacyl synthase.
 
 
 0.422
ACX96340.1
PFAM: KR domain protein; Acyl transferase; Beta-ketoacyl synthase; Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; KEGG: neu:NE1389 putative type I polyketide synthase WcbR.
 
 
 0.414
ACX96481.1
PFAM: protein of unknown function DUF1330; KEGG: ttu:TERTU_1786 hypothetical protein.
       0.414
Your Current Organism:
Halothiobacillus neapolitanus
NCBI taxonomy Id: 555778
Other names: H. neapolitanus c2, Halothiobacillus neapolitanus ATCC 23641, Halothiobacillus neapolitanus c2, Halothiobacillus neapolitanus str. c2, Halothiobacillus neapolitanus strain c2
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