STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDZ88786.1Lon-B peptidase. Serine peptidase. MEROPS family S16; Belongs to the peptidase S16 family. (705 aa)    
Predicted Functional Partners:
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
  
  
 0.927
SEA38585.1
PDZ domain-containing protein.
 
   
 0.802
dnaK
Molecular chaperone DnaK; Acts as a chaperone.
 
  
 0.794
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
 
  
 0.793
rpl40e
Large subunit ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
  
  0.723
SDZ90641.1
Thermosome subunit; Belongs to the TCP-1 chaperonin family.
  
  
 0.701
SEA22992.1
Thermosome; Belongs to the TCP-1 chaperonin family.
  
  
 0.701
SDZ88769.1
CAAX protease self-immunity.
       0.699
SDZ88800.1
Nicotinamide-nucleotide adenylyltransferase.
 
     0.678
SDZ75968.1
Small ribonucleoprotein.
  
  
  0.651
Your Current Organism:
Haloplanus vescus
NCBI taxonomy Id: 555874
Other names: CGMCC 1.8712, H. vescus, Haloplanus sp. RO5-8, Haloplanus vescus Cui et al. 2010, JCM 16055, strain RO5-8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.