B7FWU6_PHATC protein (Phaeodactylum tricornutum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

B7FWU6_PHATC

Predicted protein; Belongs to the ATP:guanido phosphotransferase family. (359 aa)

Predicted Functional Partners:

clpC

0.708

PHATR_25856

0.708

B7FUC8_PHATC

0.708

B7G704_PHATC

0.708

B7GCV2_PHATC

0.708

PK5

0.602

PGK

0.570

PK2

0.555

B7FQT4_PHATC

0.499

GAPDH_3

0.427

Your Current Organism:

Phaeodactylum tricornutum

NCBI taxonomy Id: 556484
Other names: P. tricornutum CCAP 1055/1, Phaeodactylum tricornutum CCAP 1055/1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7FQT4_PHATC	B7FWU6_PHATC	B7FQT4	B7FWU6	Predicted protein; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	0.499
B7FUC8_PHATC	B7FWU6_PHATC	B7FUC8	B7FWU6	Predicted protein.	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	0.708
B7FWU6_PHATC	B7FQT4_PHATC	B7FWU6	B7FQT4	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Predicted protein; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.	0.499
B7FWU6_PHATC	B7FUC8_PHATC	B7FWU6	B7FUC8	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Predicted protein.	0.708
B7FWU6_PHATC	B7G704_PHATC	B7FWU6	B7G704	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Predicted protein; Belongs to the ClpA/ClpB family.	0.708
B7FWU6_PHATC	B7GCV2_PHATC	B7FWU6	B7GCV2	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Predicted protein; Belongs to the ClpA/ClpB family.	0.708
B7FWU6_PHATC	GAPDH_3	B7FWU6	B7GC94	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.427
B7FWU6_PHATC	PGK	B7FWU6	B7G938	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Phosphoglycerate kinase.	0.570
B7FWU6_PHATC	PHATR_25856	B7FWU6	B5Y5I5	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Predicted protein; Belongs to the ClpA/ClpB family.	0.708
B7FWU6_PHATC	PK2	B7FWU6	B7G9H4	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.555
B7FWU6_PHATC	PK5	B7FWU6	B7G961	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.602
B7FWU6_PHATC	clpC	B7FWU6	A0T0K8	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	ATP-dependent clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.	0.708
B7G704_PHATC	B7FWU6_PHATC	B7G704	B7FWU6	Predicted protein; Belongs to the ClpA/ClpB family.	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	0.708
B7GCV2_PHATC	B7FWU6_PHATC	B7GCV2	B7FWU6	Predicted protein; Belongs to the ClpA/ClpB family.	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	0.708
GAPDH_3	B7FWU6_PHATC	B7GC94	B7FWU6	Glyceraldehyde-3-phosphate dehydrogenase.	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	0.427
GAPDH_3	PGK	B7GC94	B7G938	Glyceraldehyde-3-phosphate dehydrogenase.	Phosphoglycerate kinase.	0.975
GAPDH_3	PK2	B7GC94	B7G9H4	Glyceraldehyde-3-phosphate dehydrogenase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.717
GAPDH_3	PK5	B7GC94	B7G961	Glyceraldehyde-3-phosphate dehydrogenase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.732
PGK	B7FWU6_PHATC	B7G938	B7FWU6	Phosphoglycerate kinase.	Predicted protein; Belongs to the ATP:guanido phosphotransferase family.	0.570
PGK	GAPDH_3	B7G938	B7GC94	Phosphoglycerate kinase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.975

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

17

PPI enrichment p-value:

3.4e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

5 of 435

1.54

1.27

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045294

Alpha-catenin binding

2 of 10

2.78

0.97

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014704

Intercalated disc

2 of 11

2.74

1.28

0.0048

GO:0005911

Cell-cell junction

4 of 317

1.58

1.15

0.0032

GO:0016342

Catenin complex

2 of 30

2.31

0.98

0.0154

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37965

Cadherin-like superfamily, and Plakophilin/Delta catenin

5 of 97

2.2

3.1

5.32e-07

CL:38071

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 11

2.92

2.95

3.94e-06

CL:6049

RHOU GTPase cycle, and Unconventional class IX myosin

3 of 14

2.81

2.83

6.30e-06

CL:37972

Cadherin-like superfamily, and Plakophilin/Delta catenin

4 of 85

2.16

2.61

5.75e-06

CL:38074

Limb expression 1, and Retina layer formation

2 of 5

3.09

1.87

0.00042

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

3 of 102

1.95

1.51

0.00098

map04520

Adherens junction

3 of 115

1.9

1.49

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013026

RHOB GTPase cycle

3 of 71

2.11

1.35

0.0027

MAP-8980692

RHOA GTPase cycle

3 of 178

1.71

0.86

0.0199

MAP-5218920

VEGFR2 mediated vascular permeability

2 of 35

2.24

0.79

0.0347

MAP-418990

Adherens junctions interactions

2 of 40

2.18

0.79

0.0347

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005911

Cell-cell junction

4 of 224

1.74

1.42

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 56

2.04

0.7

0.0499

KW-0106

Calcium

3 of 368

1.39

0.62

0.0499

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046987

Unconventional class IX myosin

3 of 4

3.36

2.87

6.62e-06

IPR036023

Class IX myosin, motor domain

2 of 2

3.48

1.49

0.0021

IPR013284

Beta-catenin

2 of 3

3.31

1.47

0.0023

IPR020894

Cadherin conserved site

3 of 107

1.93

1.04

0.0100

IPR015919

Cadherin-like superfamily

3 of 122

1.87

0.99

0.0118

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00112

Cadherin repeats.

3 of 118

1.89

1.14

0.0057

SM00314

Ras association (RalGDS/AF-6) domain

2 of 30

2.31

0.94

0.0187

SM00185

Armadillo/beta-catenin-like repeats

2 of 32

2.28

0.94

0.0187

SM00242

Myosin. Large ATPases.

2 of 38

2.2

0.93

0.0187

SM00282

Laminin G domain

2 of 50

2.09

0.91

0.0199

(more ...)

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