B7G5N0_PHATC protein (Phaeodactylum tricornutum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

B7G5N0_PHATC

Predicted protein. (337 aa)

Predicted Functional Partners:

Mlh1

0.962

B7FWI1_PHATC

0.944

MSH5

0.916

MSH4

0.913

B7FP72_PHATC

0.894

B7FRE1_PHATC

0.875

PCNA

0.822

RAT1

0.804

PHATR_46734

0.734

B7G6C2_PHATC

0.734

Your Current Organism:

Phaeodactylum tricornutum

NCBI taxonomy Id: 556484
Other names: P. tricornutum CCAP 1055/1, Phaeodactylum tricornutum CCAP 1055/1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7FP72_PHATC	B7FWI1_PHATC	B7FP72	B7FWI1	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Predicted protein.	0.926
B7FP72_PHATC	B7G5N0_PHATC	B7FP72	B7G5N0	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Predicted protein.	0.894
B7FP72_PHATC	B7G6C2_PHATC	B7FP72	B7G6C2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Predicted protein.	0.832
B7FP72_PHATC	MSH4	B7FP72	B7FYF7	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.441
B7FP72_PHATC	MSH5	B7FP72	B7G2L0	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Muts-like protein 5.	0.932
B7FP72_PHATC	Mlh1	B7FP72	B7FV15	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Mutl-like protein 1.	0.970
B7FP72_PHATC	PCNA	B7FP72	B7G5K3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.954
B7FP72_PHATC	PHATR_46734	B7FP72	B5Y3L8	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Predicted protein.	0.832
B7FRE1_PHATC	B7FWI1_PHATC	B7FRE1	B7FWI1	Predicted protein.	Predicted protein.	0.931
B7FRE1_PHATC	B7G5N0_PHATC	B7FRE1	B7G5N0	Predicted protein.	Predicted protein.	0.875
B7FRE1_PHATC	B7G6C2_PHATC	B7FRE1	B7G6C2	Predicted protein.	Predicted protein.	0.832
B7FRE1_PHATC	MSH4	B7FRE1	B7FYF7	Predicted protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.423
B7FRE1_PHATC	MSH5	B7FRE1	B7G2L0	Predicted protein.	Muts-like protein 5.	0.933
B7FRE1_PHATC	Mlh1	B7FRE1	B7FV15	Predicted protein.	Mutl-like protein 1.	0.966
B7FRE1_PHATC	PCNA	B7FRE1	B7G5K3	Predicted protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.954
B7FRE1_PHATC	PHATR_46734	B7FRE1	B5Y3L8	Predicted protein.	Predicted protein.	0.832
B7FWI1_PHATC	B7FP72_PHATC	B7FWI1	B7FP72	Predicted protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.926
B7FWI1_PHATC	B7FRE1_PHATC	B7FWI1	B7FRE1	Predicted protein.	Predicted protein.	0.931
B7FWI1_PHATC	B7G5N0_PHATC	B7FWI1	B7G5N0	Predicted protein.	Predicted protein.	0.944
B7FWI1_PHATC	B7G6C2_PHATC	B7FWI1	B7G6C2	Predicted protein.	Predicted protein.	0.914

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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