STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Lreu_1407methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (152 aa)    
Predicted Functional Partners:
Lreu_1297
PFAM: methyladenine glycosylase.
      0.875
Lreu_1408
PFAM: nitroreductase.
     
 0.765
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.665
Lreu_1409
Hypothetical protein.
       0.534
Lreu_0961
PFAM: DNA/RNA non-specific endonuclease.
  
  
 0.533
dinG
DnaQ family exonuclease/DinG family helicase, putative; 3'-5' exonuclease.
     
 0.508
pheT
TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
     
 0.437
Lreu_1410
PFAM: GCN5-related N-acetyltransferase.
       0.432
Lreu_0488
Recombination protein MgsA; PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase.
 
     0.423
cinA
TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; Belongs to the CinA family.
       0.420
Your Current Organism:
Lactobacillus reuteri
NCBI taxonomy Id: 557436
Other names: L. reuteri DSM 20016, Lactobacillus reuteri DSM 20016, Lactobacillus reuteri str. DSM 20016, Lactobacillus reuteri strain DSM 20016
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.