hflK protein (Methanobrevibacter filiformis)

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Score

hflK

Modulator of FtsH protease HflK. (322 aa)

Predicted Functional Partners:

KZX17166.1

0.964

era

0.811

dnaK

0.678

ftsH_1

0.648

lon2

0.611

KZX14096.1

0.587

KZX17165.1

0.495

rpsI

0.481

rplM

0.481

nth_2

0.474

Your Current Organism:

Methanobrevibacter filiformis

NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KZX14096.1	hflK	MBFIL_09280	MBFIL_03300	Type II/IV secretion system protein.	Modulator of FtsH protease HflK.	0.587
KZX17165.1	KZX17166.1	MBFIL_03280	MBFIL_03290	NAD(P)H dehydrogenase.	Hypothetical protein; NfeD-like C-terminal, partner-binding.	0.615
KZX17165.1	hflK	MBFIL_03280	MBFIL_03300	NAD(P)H dehydrogenase.	Modulator of FtsH protease HflK.	0.495
KZX17166.1	KZX17165.1	MBFIL_03290	MBFIL_03280	Hypothetical protein; NfeD-like C-terminal, partner-binding.	NAD(P)H dehydrogenase.	0.615
KZX17166.1	hflK	MBFIL_03290	MBFIL_03300	Hypothetical protein; NfeD-like C-terminal, partner-binding.	Modulator of FtsH protease HflK.	0.964
dnaK	era	MBFIL_18650	MBFIL_17250	Chaperone protein DnaK; Acts as a chaperone.	GTPase Era.	0.559
dnaK	hflK	MBFIL_18650	MBFIL_03300	Chaperone protein DnaK; Acts as a chaperone.	Modulator of FtsH protease HflK.	0.678
dnaK	lon2	MBFIL_18650	MBFIL_18710	Chaperone protein DnaK; Acts as a chaperone.	Lon protease 2; Belongs to the peptidase S16 family.	0.944
dnaK	rplM	MBFIL_18650	MBFIL_14030	Chaperone protein DnaK; Acts as a chaperone.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.969
dnaK	rpsI	MBFIL_18650	MBFIL_14020	Chaperone protein DnaK; Acts as a chaperone.	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.969
era	dnaK	MBFIL_17250	MBFIL_18650	GTPase Era.	Chaperone protein DnaK; Acts as a chaperone.	0.559
era	hflK	MBFIL_17250	MBFIL_03300	GTPase Era.	Modulator of FtsH protease HflK.	0.811
era	lon2	MBFIL_17250	MBFIL_18710	GTPase Era.	Lon protease 2; Belongs to the peptidase S16 family.	0.635
era	rplM	MBFIL_17250	MBFIL_14030	GTPase Era.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.803
era	rpsI	MBFIL_17250	MBFIL_14020	GTPase Era.	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.803
ftsH_1	hflK	MBFIL_10240	MBFIL_03300	ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...]	Modulator of FtsH protease HflK.	0.648
ftsH_1	lon2	MBFIL_10240	MBFIL_18710	ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...]	Lon protease 2; Belongs to the peptidase S16 family.	0.561
ftsH_1	rpsI	MBFIL_10240	MBFIL_14020	ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...]	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.437
hflK	KZX14096.1	MBFIL_03300	MBFIL_09280	Modulator of FtsH protease HflK.	Type II/IV secretion system protein.	0.587
hflK	KZX17165.1	MBFIL_03300	MBFIL_03280	Modulator of FtsH protease HflK.	NAD(P)H dehydrogenase.	0.495