acsA_1 protein (Methanobrevibacter filiformis)

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Score

acsA_1

Acetyl-coenzyme A synthetase. (640 aa)

Predicted Functional Partners:

pcaF

0.935

porA

0.901

accC

0.896

porB

0.896

sucC

0.892

acsC

0.891

cdhC

0.890

acsD

0.890

leuA_2

0.883

leuA_3

0.883

Your Current Organism:

Methanobrevibacter filiformis

NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
accC	acsA_1	MBFIL_16300	MBFIL_07010	Biotin carboxylase.	Acetyl-coenzyme A synthetase.	0.896
accC	leuA_2	MBFIL_16300	MBFIL_11020	Biotin carboxylase.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.941
accC	leuA_3	MBFIL_16300	MBFIL_16920	Biotin carboxylase.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.495
accC	pcaF	MBFIL_16300	MBFIL_01510	Biotin carboxylase.	beta-ketoadipyl-CoA thiolase.	0.686
accC	porA	MBFIL_16300	MBFIL_18880	Biotin carboxylase.	Pyruvate synthase subunit PorA.	0.938
accC	porB	MBFIL_16300	MBFIL_18890	Biotin carboxylase.	Pyruvate synthase subunit PorB.	0.939
accC	sucC	MBFIL_16300	MBFIL_08520	Biotin carboxylase.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.692
acsA_1	accC	MBFIL_07010	MBFIL_16300	Acetyl-coenzyme A synthetase.	Biotin carboxylase.	0.896
acsA_1	acsC	MBFIL_07010	MBFIL_17720	Acetyl-coenzyme A synthetase.	Corrinoid/iron-sulfur protein large subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).	0.891
acsA_1	acsD	MBFIL_07010	MBFIL_17710	Acetyl-coenzyme A synthetase.	Corrinoid/iron-sulfur protein small subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.	0.890
acsA_1	cdhC	MBFIL_07010	MBFIL_17680	Acetyl-coenzyme A synthetase.	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	0.890
acsA_1	leuA_2	MBFIL_07010	MBFIL_11020	Acetyl-coenzyme A synthetase.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.883
acsA_1	leuA_3	MBFIL_07010	MBFIL_16920	Acetyl-coenzyme A synthetase.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.883
acsA_1	pcaF	MBFIL_07010	MBFIL_01510	Acetyl-coenzyme A synthetase.	beta-ketoadipyl-CoA thiolase.	0.935
acsA_1	porA	MBFIL_07010	MBFIL_18880	Acetyl-coenzyme A synthetase.	Pyruvate synthase subunit PorA.	0.901
acsA_1	porB	MBFIL_07010	MBFIL_18890	Acetyl-coenzyme A synthetase.	Pyruvate synthase subunit PorB.	0.896
acsA_1	sucC	MBFIL_07010	MBFIL_08520	Acetyl-coenzyme A synthetase.	succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.892
acsC	acsA_1	MBFIL_17720	MBFIL_07010	Corrinoid/iron-sulfur protein large subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).	Acetyl-coenzyme A synthetase.	0.891
acsC	acsD	MBFIL_17720	MBFIL_17710	Corrinoid/iron-sulfur protein large subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).	Corrinoid/iron-sulfur protein small subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.	0.999
acsC	cdhC	MBFIL_17720	MBFIL_17680	Corrinoid/iron-sulfur protein large subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.	0.999