Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KZX14916.1Mov34/MPN/PAD-1 family protein. (167 aa)    
Predicted Functional Partners:
ftsH_1
ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...]
 
 0.978
pnp_3
Polyribonucleotide nucleotidyltransferase; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
  
 0.965
rpl40e
50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.962
rpsI
30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
   
 0.940
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 0.940
eif2b
Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.
 
 0.940
prcB
Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
   
 0.912
prcA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
   
 0.912
selB
Selenocysteine-specific elongation factor; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
   
 0.911
rpsC
30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.
   
 0.896
Your Current Organism:
Methanobrevibacter filiformis
NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3
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