pflA protein (Methanobrevibacter filiformis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

pflA

Pyruvate formate-lyase 1-activating enzyme. (248 aa)

Predicted Functional Partners:

nrdD

0.947

yrrB

0.862

hisC

0.861

dapH

0.836

rmlA

0.735

coaE

0.622

moaA_1

0.530

queE

0.426

gapN

0.410

Your Current Organism:

Methanobrevibacter filiformis

NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
coaE	pflA	MBFIL_03130	MBFIL_08120	dephospho-CoA kinase.	Pyruvate formate-lyase 1-activating enzyme.	0.622
dapH	hisC	MBFIL_08140	MBFIL_08130	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase.	Histidinol-phosphate aminotransferase.	0.923
dapH	pflA	MBFIL_08140	MBFIL_08120	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase.	Pyruvate formate-lyase 1-activating enzyme.	0.836
dapH	rmlA	MBFIL_08140	MBFIL_12510	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase.	Glucose-1-phosphate thymidylyltransferase.	0.410
dapH	yrrB	MBFIL_08140	MBFIL_08110	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase.	TPR repeat-containing protein YrrB.	0.574
gapN	pflA	MBFIL_02580	MBFIL_08120	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Pyruvate formate-lyase 1-activating enzyme.	0.410
gapN	yrrB	MBFIL_02580	MBFIL_08110	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	TPR repeat-containing protein YrrB.	0.468
hisC	dapH	MBFIL_08130	MBFIL_08140	Histidinol-phosphate aminotransferase.	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase.	0.923
hisC	pflA	MBFIL_08130	MBFIL_08120	Histidinol-phosphate aminotransferase.	Pyruvate formate-lyase 1-activating enzyme.	0.861
hisC	rmlA	MBFIL_08130	MBFIL_12510	Histidinol-phosphate aminotransferase.	Glucose-1-phosphate thymidylyltransferase.	0.753
hisC	yrrB	MBFIL_08130	MBFIL_08110	Histidinol-phosphate aminotransferase.	TPR repeat-containing protein YrrB.	0.665
moaA_1	nrdD	MBFIL_01850	MBFIL_09820	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.	Anaerobic ribonucleoside-triphosphate reductase.	0.966
moaA_1	pflA	MBFIL_01850	MBFIL_08120	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.	Pyruvate formate-lyase 1-activating enzyme.	0.530
moaA_1	queE	MBFIL_01850	MBFIL_11660	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.	7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.	0.505
nrdD	moaA_1	MBFIL_09820	MBFIL_01850	Anaerobic ribonucleoside-triphosphate reductase.	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.	0.966
nrdD	pflA	MBFIL_09820	MBFIL_08120	Anaerobic ribonucleoside-triphosphate reductase.	Pyruvate formate-lyase 1-activating enzyme.	0.947
nrdD	queE	MBFIL_09820	MBFIL_11660	Anaerobic ribonucleoside-triphosphate reductase.	7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.	0.971
nrdD	yrrB	MBFIL_09820	MBFIL_08110	Anaerobic ribonucleoside-triphosphate reductase.	TPR repeat-containing protein YrrB.	0.411
pflA	coaE	MBFIL_08120	MBFIL_03130	Pyruvate formate-lyase 1-activating enzyme.	dephospho-CoA kinase.	0.622
pflA	dapH	MBFIL_08120	MBFIL_08140	Pyruvate formate-lyase 1-activating enzyme.	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase.	0.836