cobB_2 protein (Methanobrevibacter filiformis)

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cobB_2

NAD-dependent protein deacetylase. (50 aa)

Predicted Functional Partners:

KZX12520.1

0.976

nadE

0.952

nadK

0.949

KZX15118.1

0.936

recQ

0.812

dnaJ

0.791

KZX16023.1

0.777

prs

0.764

dnaK

0.699

yhaO

0.646

Your Current Organism:

Methanobrevibacter filiformis

NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KZX12520.1	KZX15118.1	MBFIL_11240	MBFIL_07190	Bifunctional NMN adenylyltransferase/nudix hydrolase.	Putative nicotinate phosphoribosyltransferase.	0.959
KZX12520.1	cobB_2	MBFIL_11240	MBFIL_09490	Bifunctional NMN adenylyltransferase/nudix hydrolase.	NAD-dependent protein deacetylase.	0.976
KZX12520.1	nadE	MBFIL_11240	MBFIL_11560	Bifunctional NMN adenylyltransferase/nudix hydrolase.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.967
KZX12520.1	nadK	MBFIL_11240	MBFIL_02150	Bifunctional NMN adenylyltransferase/nudix hydrolase.	NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.947
KZX15118.1	KZX12520.1	MBFIL_07190	MBFIL_11240	Putative nicotinate phosphoribosyltransferase.	Bifunctional NMN adenylyltransferase/nudix hydrolase.	0.959
KZX15118.1	cobB_2	MBFIL_07190	MBFIL_09490	Putative nicotinate phosphoribosyltransferase.	NAD-dependent protein deacetylase.	0.936
KZX16023.1	cobB_2	MBFIL_05660	MBFIL_09490	Hypothetical protein.	NAD-dependent protein deacetylase.	0.777
cobB_2	KZX12520.1	MBFIL_09490	MBFIL_11240	NAD-dependent protein deacetylase.	Bifunctional NMN adenylyltransferase/nudix hydrolase.	0.976
cobB_2	KZX15118.1	MBFIL_09490	MBFIL_07190	NAD-dependent protein deacetylase.	Putative nicotinate phosphoribosyltransferase.	0.936
cobB_2	KZX16023.1	MBFIL_09490	MBFIL_05660	NAD-dependent protein deacetylase.	Hypothetical protein.	0.777
cobB_2	dnaJ	MBFIL_09490	MBFIL_18660	NAD-dependent protein deacetylase.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.791
cobB_2	dnaK	MBFIL_09490	MBFIL_18650	NAD-dependent protein deacetylase.	Chaperone protein DnaK; Acts as a chaperone.	0.699
cobB_2	nadE	MBFIL_09490	MBFIL_11560	NAD-dependent protein deacetylase.	NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.	0.952
cobB_2	nadK	MBFIL_09490	MBFIL_02150	NAD-dependent protein deacetylase.	NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.949
cobB_2	prs	MBFIL_09490	MBFIL_18720	NAD-dependent protein deacetylase.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).	0.764
cobB_2	recQ	MBFIL_09490	MBFIL_09800	NAD-dependent protein deacetylase.	ATP-dependent DNA helicase RecQ.	0.812
cobB_2	yhaO	MBFIL_09490	MBFIL_01460	NAD-dependent protein deacetylase.	Putative metallophosphoesterase YhaO; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.	0.646
dnaJ	cobB_2	MBFIL_18660	MBFIL_09490	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	NAD-dependent protein deacetylase.	0.791
dnaJ	dnaK	MBFIL_18660	MBFIL_18650	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Chaperone protein DnaK; Acts as a chaperone.	0.999
dnaJ	prs	MBFIL_18660	MBFIL_18720	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).	0.717