| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KZX13503.1 | ftsH_1 | MBFIL_10250 | MBFIL_10240 | Transcription factor. | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | 0.755 |
| KZX13503.1 | rpl40e | MBFIL_10250 | MBFIL_05930 | Transcription factor. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.899 |
| KZX13503.1 | rpsE | MBFIL_10250 | MBFIL_16530 | Transcription factor. | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. | 0.846 |
| KZX13503.1 | tgt_1 | MBFIL_10250 | MBFIL_06670 | Transcription factor. | Queuine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.791 |
| KZX13503.1 | tuf | MBFIL_10250 | MBFIL_04790 | Transcription factor. | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. | 0.563 |
| KZX14916.1 | ftsH_1 | MBFIL_07810 | MBFIL_10240 | Mov34/MPN/PAD-1 family protein. | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | 0.978 |
| KZX14916.1 | ftsH_2 | MBFIL_07810 | MBFIL_12420 | Mov34/MPN/PAD-1 family protein. | ATP-dependent zinc metalloprotease FtsH. | 0.763 |
| KZX14916.1 | prcA | MBFIL_07810 | MBFIL_10850 | Mov34/MPN/PAD-1 family protein. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.912 |
| KZX14916.1 | prcB | MBFIL_07810 | MBFIL_02700 | Mov34/MPN/PAD-1 family protein. | Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.912 |
| KZX14916.1 | rad50 | MBFIL_07810 | MBFIL_01470 | Mov34/MPN/PAD-1 family protein. | Putative DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.428 |
| KZX14916.1 | rpl40e | MBFIL_07810 | MBFIL_05930 | Mov34/MPN/PAD-1 family protein. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.962 |
| KZX14916.1 | rpsE | MBFIL_07810 | MBFIL_16530 | Mov34/MPN/PAD-1 family protein. | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. | 0.871 |
| KZX14916.1 | tuf | MBFIL_07810 | MBFIL_04790 | Mov34/MPN/PAD-1 family protein. | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. | 0.561 |
| ftsH_1 | KZX13503.1 | MBFIL_10240 | MBFIL_10250 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | Transcription factor. | 0.755 |
| ftsH_1 | KZX14916.1 | MBFIL_10240 | MBFIL_07810 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | Mov34/MPN/PAD-1 family protein. | 0.978 |
| ftsH_1 | ftsH_2 | MBFIL_10240 | MBFIL_12420 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | ATP-dependent zinc metalloprotease FtsH. | 0.677 |
| ftsH_1 | prcA | MBFIL_10240 | MBFIL_10850 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.959 |
| ftsH_1 | prcB | MBFIL_10240 | MBFIL_02700 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | Proteasome subunit beta precursor; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.968 |
| ftsH_1 | rad50 | MBFIL_10240 | MBFIL_01470 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | Putative DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.797 |
| ftsH_1 | rpl40e | MBFIL_10240 | MBFIL_05930 | ATP-dependent zinc metalloprotease FtsH; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes AT [...] | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.932 |
