Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KZX11542.1Histone-like transcription factor (CBF/NF-Y) and archaeal histone. (71 aa)    
Predicted Functional Partners:
thrS
threonine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
     0.526
KZX10746.1
Hypothetical protein.
  
     0.513
KZX14096.1
Type II/IV secretion system protein.
  
     0.508
polB
DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
  
  
  0.486
tfe
Transcription initiation factor E subunit alpha; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...]
  
   
 0.482
KZX15375.1
DHHA1 domain protein.
  
     0.475
recJ
single-stranded-DNA-specific exonuclease RecJ.
  
     0.444
KZX16985.1
tRNA-splicing endonuclease subunit alpha.
  
     0.438
thrB_2
Homoserine kinase.
  
     0.432
KZX12635.1
Hypothetical protein.
  
     0.429
Your Current Organism:
Methanobrevibacter filiformis
NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3
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