STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
secEProtein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (59 aa)    
Predicted Functional Partners:
secY
Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 0.960
rpl31e
50S ribosomal protein L31e; Belongs to the ribosomal protein L31e family.
 
   0.958
rpsI
30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.942
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 
 0.942
rpl18a
50S ribosomal protein LX.
 
   0.941
rplK
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.
 
   0.939
rps19e
30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family.
 
   0.926
rpl34e
50S ribosomal protein L34e; Belongs to the eukaryotic ribosomal protein eL34 family.
  
   0.923
rpmC
50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family.
  
   0.894
rps28e
30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.
   
   0.891
Your Current Organism:
Methanobrevibacter filiformis
NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3
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