Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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[Homology]
Score
cbiXSirohydrochlorin cobaltochelatase. (314 aa)    
Predicted Functional Partners:
sirC
Precorrin-2 dehydrogenase.
  
 
 0.851
KZX10310.1
Hypothetical protein.
       0.791
cbiX-2
Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
 
    
0.786
sumT
uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
 0.775
cobB_1
Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
 
  
 0.748
KZX17605.1
Cobalamin biosynthesis protein CbiG.
 
  
 0.738
cbiE
Putative cobalt-precorrin-6Y C(5)-methyltransferase.
 
  
 0.723
cbiL
Cobalt-precorrin-2 C(20)-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.716
cbiT
Putative cobalt-precorrin-6Y C(15)-methyltransferase; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
    
 0.650
cbiH
cobalt-precorrin-3B C(17)-methyltransferase.
 
  
 0.610
Your Current Organism:
Methanobrevibacter filiformis
NCBI taxonomy Id: 55758
Other names: DSM 11501, M. filiformis, strain RFM-3
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